The invention relates to an arrangement (1) for non-invasively characterising cerebrospinal fluid and other bodily fluids, • comprising a sensor head (7) for emitting terahertz radiation (T) and receiving its reflections (R), which sensor head, during use, is applied to the patient (3) in such a way that the terahertz radiation (T) radiates into the bodily fluid, • comprising an electronic evaluation circuit for calculating measurement data from the emitted and received radiation (T, R), wherein this circuit automatically determines the extinction of different wavelengths and, from this, calculates the concentration of different substances in the bodily fluid, • and comprising a display (8) for optically representing the data calculated by the evaluation circuit as results.

• 출원번호 : EP2024/071758
• 출원인 : LALA, Helin;LALA, Sultan;
• 특허번호 :
• IPC : G01N-021/3581(2014.01);A61B-005/00(2006.01);A61B-005/0507(2021.01);A61B-005/145(2006.01);

The present disclosure relates to a pharmaceutical composition comprising Lu-PSMA I&T and methods of administering the same. The administration of the composition results in a low absorbed radiation dose per gram of tissue in a human patient's body, including the kidneys, gastrointestinal tract, left colon, liver, rectum, red marrow, spleen, lacrimal glands, and salivary glands.

• 출원번호 : US2024/040449
• 출원인 : CURIUM US LLC
• 특허번호 :
• IPC : A61K-051/08(2006.01);A61P-013/08(2006.01);A61K-006/50(2020.01);

Present invention discloses a novel method for cervical cancer patients undergoing brachytherapy which combines a rectal retractor (RR) blade with radio-opaque vaginal packing (VP) to displace the rectum and bladder away from radiation sources in High-dose-rate (HDR) intracavity brachytherapy (ICB). While doing conventional brachytherapy with T&R applicators, the inventors deliberately placed radio-opaque vaginal packing (VP), posterior and cranial to the rectal retractor (RR) blade, to retract the rectum away from the radiation sources. The combination procedure Rectal retractor (RR) and Radio-opaque vaginal opaque (VP) is less time consuming and leads to significant reduction in dose to ICRU rectal points to 13.03% and reduction in rectal dose per fraction is 15% (p = 0.013).

• 출원번호 : IN2024/051420
• 출원인 : VATS, Dr. Siddharth;-, Dr Shabnum;GUPTA, Dr Manish;CHANDRAKANT, Dr Lalit;
• 특허번호 :
• IPC : A61N-005/00(2006.01);A61B-017/02(2006.01);

The present invention inter alia relates to a chimeric human CD8 Co-receptor, wherein the CD8 Co-receptor comprises a polypeptide including at least one functional polypeptide domain or a functional polypeptide motif of a wildtype human CD8α Co- receptor, and wherein said polypeptide further comprises at least one CD8β-derived polypeptide region including a functional polypeptide domain or a functional polypeptide motif of a wildtype human CD8β Co-receptor.The present invention also relates to a nucleic acid encoding the chimeric CD8 Co-receptor, a vector comprising the nuclear acid encoding for the chimeric human CD8 Co-receptor, as well as to isolated T-cells being transduced with the nucleic acid or the with the vector, and to isolated T-cells being transduced to express the chimeric CD8 Co-receptor. The invention further relates to a kit for preparing the isolated T-cells of the present invention, as well as to a pharmaceutical composition comprising the T-cells. The invention also relates to a method for preparing a T-cell for immunotherapy, and to a method for treating a patient having cancer comprising administering the pharmaceutical composition.

• 출원번호 : EP2024/071706
• 출원인 : T-KNIFE GMBH
• 특허번호 :
• IPC : A61K-039/00(2006.01);A61P-035/00(2006.01);C07K-014/705(2006.01);

The present invention relates to an apparatus (100) and a process for treating activated and/or contaminated components (90). In particular, the apparatus (100) comprises a container (10) comprising an internal volume (V). The container (10) is provided with a closure element (20) which is movable between an operating opening configuration of the container (10) and an operating closing configuration thereof. The apparatus (100) further comprises an inflatable joint (50), configured to operate in association with said closure element (20) so as to achieve a watertight sealing of the container (10) when said container is in the operating closing configuration. The apparatus (100) further comprises a cutting device (40) arranged inside the internal volume (V) of said container (10), at least one effluent treatment device (60) and at least one fluid suction device (70) communicating with the internal volume (V) of said container (10) and with said treatment device (60) of an effluent.

• 출원번호 : IB2024/057417
• 출원인 : GREEN-LAND SRL
• 특허번호 :
• IPC : G21F-009/34(2006.01);B01D-021/00(2006.01);G21F-009/36(2006.01);

Method of manufacturing semiconductor device includes forming photoresist layer over substrate. Forming photoresist layer includes combining first precursor and second precursor in vapor state to form photoresist material, wherein first precursor is organometallic having formula: MaRbXc, where M at least one of Sn, Bi, Sb, In, Te, Ti, Zr, Hf, V, Co, Mo, W, Al, Ga, Si, Ge, P, As, Y, La, Ce, Lu; R is substituted or unsubstituted alkyl, alkenyl, carboxylate group; X is halide or sulfonate group; and 1≤a≤2, b≥1, c≥1, and b+c≤5. Second precursor is at least one of an amine, a borane, a phosphine. Forming photoresist layer includes depositing photoresist material over the substrate. The photoresist layer is selectively exposed to actinic radiation to form latent pattern, and the latent pattern is developed by applying developer to selectively exposed photoresist layer to form pattern.

• 출원번호 : 18790000
• 출원인 : Taiwan Semiconductor Manufacturing Company, Ltd.
• 특허번호 :
• IPC : G03F-007/16(2006.01);G03F-007/11(2006.01);G03F-007/20(2006.01);H01L-021/027(2006.01);

Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. The disclosure provides fusion proteins of nucleic acid programmable DNA binding proteins (napDNAbp), e.g., Cas9 or variants thereof, and nucleic acid editing proteins such as cytidine deaminase domains (e.g., novel cytidine deaminases generated by ancestral sequence reconstruction), and adenosine deaminases that deaminate adenine in DNA. Aspects of the disclosure relate to fusion proteins (e.g., base editors) that have improved expression and/or localize efficiently to the nucleus. In some embodiments, base editors are codon optimized for expression in mammalian cells. In some embodiments, base editors include multiple nuclear localization sequences (e.g., bipartite NLSs), e.g., at least two NLSs. In some embodiments, methods for targeted nucleic acid editing are provided.

• 출원번호 : 18791223
• 출원인 : The Broad Institute, Inc.
• 특허번호 :
• IPC : C07K-014/47(2006.01);C12N-009/22(2006.01);C12N-009/78(2006.01);

Provided is an integrated circuit capable of maintaining high reliability even under a severe environment such as a high radiation environment.　An integrated circuit 1 comprises: a master latch 3 for receiving an input of an input signal, and outputting a signal at a timing based on a master clock signal; and N (N is an odd number of 3 or more) slave latches 4 for receiving an input of the signal outputted from the master latch 3, and outputting an output signal at a timing based on a slave clock signal. The master latch 3 outputs, to the slave latches 4, a signal of a value determined on the basis of the input signal and the input of the outputted signal. Each of the slave latches 4 is configured to output an output signal of a value determined on the basis of a majority decision result of signals respectively outputted from the N slave latches 4 or a majority decision result of signals, which the slave latches 4 have respectively received, as inputs, from the master latch 3.

• 출원번호 : JP2024/027345
• 출원인 : NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
• 특허번호 :
• IPC : H03K-003/037(2006.01);H03K-019/23(2006.01);H03K-019/096(2006.01);

The present invention inter alia relates to an enhanced chimeric CD8 Co-receptor, wherein the CD8 Co-receptor comprises a polypeptide including at least one functional polypeptide domain or a functional polypeptide motif of a CD8 Co-receptor, and wherein said polypeptide further comprises at least one CD8-derived polypeptide region including a functional polypeptide domain or a functional polypeptide motif of a wildtype human CD8 Co-receptor.The enhanced chimeric CD8 Co-receptor further comprises at least one cytoplasmic polypeptide domain or cytoplasmic polypeptide motif of a tumor necrosis factor receptor superfamily protein, a immunoglobulin superfamily (IgSF) protein, and/or an ITAM-associated receptor. The present invention also relates to a nucleic acid encoding the enhanced chimeric CD8 Co-receptor, a vector comprising the nuclear acid encoding for the enhanced chimeric human CD8 Co-receptor, as well as to isolated T-cells being transduced, transformed or transfected with the nucleic acid or the with the vector, and to isolated T-cells being transduced, transformed or transfected to express the enhanced chimeric CD8 Co-receptor as well as to engineered T-cells expressing the chimeric CD8 Co-receptor. The invention further relates to a kit for preparing the isolated T-cells of the present invention, as well as to a pharmaceutical composition comprising the T-cells. The invention also relates to a method for preparing a T-cell for immunotherapy, and to a method for treating a patient having a disease comprising administering the pharmaceutical composition.

• 출원번호 : EP2024/071709
• 출원인 : T-KNIFE GMBH
• 특허번호 :
• IPC : C07K-014/73(2006.01);C07K-014/705(2006.01);A61K-038/00(2006.01);

An object of the present invention is to provide a composite oxide particle material formed of zinc molybdate having a high purity and a high circularity. The composite oxide particle material is formed of a composite oxide, of molybdenum and zinc, having an average particle diameter of 0.1 μm or more and 5.0 μm or less, a BET specific surface area of 1 m2/g or more and 20 m2/g or less, (peak intensity at 26.6° according to XRD)/(peak intensity at 24.2°) of 1.20 or more, an impurity concentration of 1 mass % or less, and a circularity of 0.90 or more. XRD is measured with CuKα radiation.

• 출원번호 : 18790034
• 출원인 : ADMATECHS CO., LTD.
• 특허번호 :
• IPC : C08K-009/06(2006.01);C01G-039/00(2006.01);C09C-001/00(2006.01);C09C-003/12(2006.01);