Provided herein are methods and compositions for disrupting expression of nuclear receptor interacting protein 1 (Nrip1) in adipose cells. and methods of use of such adipose cells for treating, or reducing risk of, a condition associated with an elevated body mass index (BMI).

• 출원번호 : 18672796
• 출원인 : Czech, Michael P.
• 특허번호 :
• IPC : C12N-009/22(2006.01);A61K-035/35(2006.01);A61P-003/04(2006.01);C12N-005/077(2006.01);C12N-015/11(2006.01);C12N-015/90(2006.01);

A vibration estimation system for estimating vibration of at least one target, comprising a transceiver; a radiating antenna arranged and configured to radiate an electromagnetic transmit signal from the transceiver in a transmission direction with a radiation pattern comprising a main lobe having a distance-dependent extension in a plane perpendicular to the transmission direction, and to return to the transceiver an electromagnetic reflection signal resulting from reflection of the transmit signal at the at least one target, when the at least one target is located within the distance-dependent extension of the main lobe of the transmit signal; processing circuitry coupled to the transceiver and configured to estimate the vibration of the target based on a difference between the transmit signal and the reflection signal; and an aiming arrangement arranged and configured to provide a visible aiming pattern visually indicating the distance-dependent extension of the main lobe of the transmit signal.

• 출원번호 : 18672111
• 출원인 : Delin, Håkan
• 특허번호 :
• IPC : G01M-005/00(2006.01);G01S-007/35(2006.01);G01S-013/36(2006.01);G01S-013/88(2006.01);

A high-temperature gas-cooled reactor (HTGR) core is disclosed which includes a plurality of nuclear fuel kernels encapsulated by i) solid structures; and ii) porous structures, wherein the solid structures and the porous structures form a heterogeneous tileable repeating assembly including a channel for moving heat out of the HTGR core, wherein a ratio of in-channel porosity to in-channel tortuosity of the assembly is between about 0.2 to about 0.5, wherein the in-channel tortuosity is between about 1.0 and 1.6, and wherein total solid fraction of the assembly is between about 0.6 to about 0.85.

• 출원번호 : 18672891
• 출원인 : Purdue Research Foundation
• 특허번호 :
• IPC : G21C-015/253(2006.01);G21C-005/12(2006.01);G21C-015/16(2006.01);

The invention relates to a protective label for a container (200), having: - a flat barrier layer (103) which produces a barrier function against the passage of a fluid and/or electromagnetic radiation, - a first label section (101) which is designed to be secured to a first container section (201) of the container (200), and - a second label section (102) which adjoins the first label section (101) along a first direction (104) and which is designed to be secured to a second container section (202) of the container (200), wherein the first container section (201) and the second container section (202) are oriented at an angle to each other, and the second label section (102) has a plurality of label fingers (106, 107, 108) which can be tilted relative to one another. Each of the label fingers (106, 107, 108) has an adhesive region (111) at least at one end (109) which faces away from the first label section (101) along the first direction (104), and the label fingers (106, 107, 108) are designed to cover the second container section (102) when the label fingers are applied.

• 출원번호 : EP2024/064157
• 출원인 : SCHREINER GROUP GMBH &CO. KG;
• 특허번호 :
• IPC : G09F-003/02(2006.01);G09F-003/10(2006.01);

The invention relates to a substrate with a mark consisting of microscopic metallurgical structures (3) arranged randomly on the surface of the substrate and having at least one physical and/or chemical property different from the rest of the substrate. At least one structure comprises an element such that exposing the mark to radiation or to an external electrical or magnetic field or to a chemical attack or to mechanical, thermal or electrical stress induces a temporary or permanent change of at least one physical or chemical property of the structure. The structures may be a different first alloy (31) and second alloy (32). The alloy 31 changes colour in a stable and definitive manner after exposure to laser radiation while the alloy 32 has a high reflectivity and is therefore stable to laser exposure.

• 출원번호 : IB2024/055025
• 출원인 : UNIVERSITÉDE GENEVE;
• 특허번호 :
• IPC : B42D-025/305(2014.01);B42D-025/36(2014.01);B42D-025/373(2014.01);B42D-025/41(2014.01);B42D-025/445(2014.01);

A far field radiation pattern is determined for a multi-element antenna array (1) comprising a plurality of antenna elements (2a, 2b) disposed in a first plane (6) using test apparatus comprising a support member (4) for holding the multi-element array (1) and a movable probe (3) having an aperture configured to be movable in a second plane (5) parallel to the first plane (6). A distance between the first plane (6) and the second plane (5) is less than a quarter of a wavelength at an operating frequency of the multi-element antenna array. The movable probe tis caused to radiate electromagnetic energy from the aperture and is moved in a determined trajectory in the second plane (5). A respective measurement of amplitude and phase of electromagnetic energy received by the multi-element antenna array is taken at each of a plurality of positions on the determined trajectory. The far field radiation pattern is determined from the respective measurements and from a pre-determined radiation pattern for at least one antenna element of the plurality of antenna elements.

• 출원번호 : 24177807.5
• 출원인 : Cambium Networks Ltd
• 특허번호 :
• IPC : G01R-029/10(2006.01)

• 출원번호 : 24177724.2
• 출원인 : Sidel Participations
• 특허번호 :
• IPC : B29C-049/42(2006.01);B29C-049/64(2006.01);B29C-049/68(2006.01);B29C-049/78(2006.01);B29C-049/06(2006.01);B29K-067/00(2006.01);B29L-031/00(2006.01);

Described herein, are methods of determining an absolute risk reduction (AAR) of disease progression in a subject. Specifically, the present disclosure provides, among other things, methods for determining AAR in a subject receiving androgen deprivation therapy (ADT) and radiotherapy (RT) compared to RT alone where the absolute risk reduction is a measure of the likelihood of metastasis.

• 출원번호 : US2024/030876
• 출원인 : MYRIAD GENETICS, INC.
• 특허번호 :
• IPC : G16B-020/00(2019.01);C12Q-001/6886(2018.01);

A method includes forming a plurality of first mandrels over a substrate, forming an overcoat layer over the plurality of first mandrels, and inducing a crosslinking reaction within the overcoat layer and form a crosslinked overcoat layer. The method further includes exposing the substrate to a radiation to generate a plurality of acid molecules within the plurality of first mandrels, diffusing a portion of the plurality of acid molecules from the plurality of first mandrels into portions of the crosslinked overcoat layer, and inducing a decrosslinking reaction within the portions of the crosslinked overcoat layer and form de-crosslinked regions. Unmodified regions of the crosslinked overcoat layer form a plurality of second mandrels. The method further includes selectively removing the de-crosslinked regions. The plurality of first mandrels and the plurality of second mandrels form a mandrel pattern over the substrate.

• 출원번호 : US2024/030882
• 출원인 : TOKYO ELECTRON LIMITED;TOKYO ELECTRON U.S. HOLDINGS, INC.;
• 특허번호 :
• IPC : H01L-021/027(2006.01);G03F-007/00(2006.01);G03F-007/16(2006.01);G03F-007/26(2006.01);

The present invention is a system for providing accurate image-guided localization of a radiation target using digital image acquisition with real time data analysis utilizing a radiation device, directing a beam of radiation through a sample reflecting onto a film screen and reflecting an image from the film screen onto a mirror that will project the image from the mirror to a bean splitter where it is captured by a camera operatively associated with a computer device.

• 출원번호 : 18673272
• 출원인 : Wu, Xiaodong
• 특허번호 :
• IPC : A61N-005/10(2006.01)