Water-soluble nanoclusters that include gold, and a bisTV-heterocyclic carbene ligand that includes at least one water soluble moiety are described. The water soluble moiety comprises a polyether, a carboxylic acid, a carboxylate, an ammonium group, a sugar, or a protein. The water soluble moiety is located on the wingtips of the bisNHC ligands or the water soluble moiety is located on the backbone of the bisNHC ligands. The nanocluster may further comprise a targeting ligand such as a derivative of folic acid, or the metal nanocluster may further comprise at least one clickable group such as an azide. As described herein, the water-soluble Atir, nanoclustcrs protected by NHC ligands have been synthesized and characterized. Their water solubility properties aid in biomedical testing and application of this material. Applications for the nanoclusters include photosensitizing and cell imaging due to the properties of luminescence when exposed to radiation.

• 출원번호 : CA2024/050729
• 출원인 : QUEEN'S UNIVERSITY AT KINGSTON;NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM;
• 특허번호 :
• IPC : C07D-235/04(2006.01);A61K-041/00(2020.01);A61K-049/00(2006.01);A61P-035/00(2006.01);B01J-019/08(2006.01);C07D-403/10(2006.01);C07D-519/00(2006.01);C07H-015/26(2006.01);C07K-016/00(2006.01);C07K-016/28(2006.01);C09K-011/06(2006.01);C12M-001/34(2006.01);G01D-005/26(2006.01);G01N-021/62(2006.01);G01N-024/08(2006.01);G01R-033/28(2006.01);H10K-030/35(2023.01);H10K-030/50(2023.01);

Disclosed herein are 6-thiopurine containing dimer compounds of formula I: or a pharmaceutically acceptable salt, ester, prodrug, hydrate, or tautomer thereof, wherein both Rs are concurrently H, or (PO), and both Rs are concurrently H or OH. Methods for preparing the compounds of formula I from the corresponding 6-thiopurine containing monomer compounds are also disclosed. Also disclosed are methods for converting the dimer compounds of Formula I to the corresponding 6-thiopurine containing monomer compounds. The compounds are useful for treating, ameliorating, or preventing various types of cancer, particularly those that are drug resistant. The compounds of Formula I can also be used in conjunction with a checkpoint inhibitor and/or radiation in different ways for treating various types of cancer.

• 출원번호 : US2024/031754
• 출원인 : MAIA BIOTECHNOLOGY, INC.
• 특허번호 :
• IPC : C07H-019/173(2006.01);C07H-019/19(2006.01);C07H-019/20(2006.01);A61P-035/00(2006.01);A61K-031/7076(2006.01);

The present disclosure provides compounds of formula I, II, or III or pharmaceutically acceptable salts thereof, wherein R-R, R-R, R, R, and R are defined herein. Also provided are compositions comprising the compounds, methods of using the compounds for delivering radiation to dihydrofolate reductase (DHFR) expressing cells or tissues, killing a cell or tissue comprising dihydrofolate reductase (eDHFR), or treating a cancer in a subject in need thereof.

• 출원번호 : US2024/031640
• 출원인 : THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
• 특허번호 :
• IPC :

시스템이 기판 상의 광경화성 조성물을 가열하기 위한 제1 가열 수단; 700 nm 미만의 파장으로 화학 방사선을 방출하도록 구성된 화학 방사선 소스; 및 광경화성 조성물이 화학 방사선 소스에 의해 노출될 때 광경화성 조성물의 광경화 온도를 달성하기 위해 제1 가열 수단에 의해 생성될 목표 온도를 결정하도록 구성된 제어기를 포함할 수 있으며, 광경화 온도는 주위 온도보다 높다.방법이 기판 상에 광경화성 조성물을 분배하는 단계; 경화된 층을 형성하기 위해 광경화성 조성물의 층을 주위 온도보다 높은 광경화 온도에서 광경화시키는 단계; 및 베이킹된 층을 형성하기 위해 경화된 층을 베이킹하는 단계를 포함할 수 있다.시스템 및 방법은 층의 두께 변화가 0% 또는 0%에 더 근접하게 할 수 있다.

• 출원번호 : 10-2024-0069842
• 출원인 : 캐논 가부시끼가이샤
• 특허번호 :
• IPC : G03F-007/00;H01L-021/3105;H01L-021/67;

The present invention relates to a method for manufacturing a contact lens, comprising: a first step of preparing a raw material in which 2-methacryloyloxyethyl phosphorylcholine (MPC) is dispersed; a second step of mixing the raw material with a hydrophilic monomer and an additive; and a third step of injecting the mixture obtained in the second step into a mold for manufacturing a contact lens, and then polymerizing same to obtain a contact lens. According to the present invention, the method for manufacturing a contact lens, of the present invention, can improve the functional characteristics of a contact lens due to the inclusion of a large amount of a raw material which is difficult to measure and control, such as MPC, through a step of preparing a raw material in which MPC is dispersed, can improve the mechanical properties of a contact lens since, when a primarily cross-linked raw material is used as a raw material of the contact lens, cross-linking control is possible during polymerization of total raw materials of the contact lens, thus suppressing residual unreacted monomers in a polymer, and can also resolve problems caused by the use of a cross-linker and an initiator, by carrying out a polymerization reaction of raw materials through irradiation of radiation or infrared rays.

• 출원번호 : KR2024/007306
• 출원인 : THE SOP CORPORATION CO., LTD.;MYUNG, Jae Hong;MOON, Seung Heyn;
• 특허번호 :
• IPC : C08F-230/08(2006.01);C08F-220/20(2006.01);C08F-230/02(2006.01);C08J-003/28(2006.01);B29D-011/00(2006.01);

Systems and methods for mapping temperature in an environment using photoluminescent thermosensitive agents are described. In an embodiment, a method comprises disposing a population of photoluminescent thermosensitive agents in the environment, the population having first and second switching temperature thresholds, exposing the environment to an activation source to create an activation region having a temperature greater than or equal to the first switching temperature threshold, exposing the environment to electromagnetic radiation, and detecting a photoluminescent signal emitted at a first time. A method can further comprise exposing the environment to an activation source to increase the temperature of the activation region to a temperature greater than or equal to the second switching temperature threshold, exposing the environment to electromagnetic radiation, and detecting a photoluminescent signal emitted at a second time.

• 출원번호 : US2024/031427
• 출원인 : BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
• 특허번호 :
• IPC : G01N-021/64(2006.01);G01N-033/542(2006.01);A61B-005/00(2006.01);A61B-008/08(2006.01);A61K-049/00(2006.01);G01K-011/20(2006.01);

A tile for heat insulation has a body forming an enclosure. The body can be aluminum or aluminum alloy material. Inside the enclosure one or more panels of reflective material are disposed and divide the enclosure into two or more separate sub-chambers. The tile inhibits conduction, convection and radiation heat transfer therethrough. The tile can be a rectangular box (e.g., have planar surfaces) for insulating a home or building, or can be curved with a C-shape to allow the tile to conform to a curved surface, such as a vessel (e.g., tank, pipe) having a circular perimeter, or can have an S-shape to provide a roof tile.

• 출원번호 : US2024/031442
• 출원인 : IDEALAB STUDIO, LLC
• 특허번호 :
• IPC : E04D-001/06(2006.01);E04B-001/80(2006.01);E04D-011/02(2006.01);

Provided is a LiDAR system for a vehicle capable of optimizing light distribution of a laser beam irradiating an irradiation area, while simplifying the structure of an irradiation-side optical system. A lens 58 of an irradiation device 12 of a LiDAR system 10 has a reflection surface 69n of a conical side surface in which a vertex T68n is on a light source 33n side and a center axis (auxiliary line C68n) is deviated with respect to an optical axis (auxiliary line C33n) of a light source 33n, and reflects a laser beam from the light source 33n in a radiation direction on a reflection surface 69n.

• 출원번호 : JP2024/019775
• 출원인 : STANLEY ELECTRIC CO., LTD.
• 특허번호 :
• IPC : G01S-007/481(2006.01);G01S-017/931(2020.01);

An optoelectronic device including a support including a face; light-emitting diodes lying on the face and including semiconductor elements in the form of wires, cones or truncated cones; for each light-emitting diode, an encapsulation block at least partially transparent to the radiation emitted by the light-emitting diodes and covering the light-emitting diode, the maximum thickness of the encapsulation block being comprised between 1 μm and 30 μm, interstices of air being present between the encapsulation blocks covering adjacent diodes; and an electrically conductive layer covering the encapsulation blocks, wherein the refractive index of the encapsulation block covering at least one of the light-emitting diodes is comprised between 1.3 and 1.6.

• 출원번호 : 18676771
• 출원인 : Aledia
• 특허번호 :
• IPC : H01L-025/13(2006.01);H01L-033/20(2006.01);H01L-033/32(2006.01);H01L-033/54(2006.01);H01L-033/58(2006.01);H01L-033/62(2006.01);

The present invention relates to a blind spot alert system designed for alerting vehicles approaching from multiple directions. The system includes a housing mounted at a strategic location, equipped with a comprehensive sensor sub-system. This sub-system includes Passive Infrared (PIR) sensors to detect thermal radiation of animate entities, Light Detection and Ranging (LIDAR) sensors to measure vectored distances of surrounding objects, Ultrasonic sensors for non-vectored distance measurement, and Doppler speed measurement sensors to capture vehicle velocity and trajectory. A microcontroller processes the data from these sensors, analyses it to detect potential threats, and generates appropriate warning signals. These warning signals are transmitted to an indicator sub-system that provides visual or audible alerts to the approaching vehicles. Additionally, the system includes a server that receives and stores the analyzed data for further processing or record-keeping.

• 출원번호 : 18676921
• 출원인 : Karimian, Behrooz
• 특허번호 :
• IPC : G08G-001/095(2006.01);G01S-013/931(2006.01);G01S-017/931(2006.01);G08G-001/16(2006.01);