The present paper analyzes the individual effects of three dimensions of knowledge management on product and process innovations in the field of PV/T technologies. Forms of a specially prepared questionnaire were adequately filled in by 300 Serbian companies who already use, produce or plan to produce some PV/T technology. The collected data were analyzed by means of the partial least squares structural equation modeling algorithm in the partial least squares path modeling software package version 0.5.0. The survey was conducted in the period from May to September 2023 in 300 small- and medium-sized companies. The findings show that knowledge acquisition, knowledge storage, and knowledge sharing, as dimensions of knowledge management, have positive effects on the implementation of product and process innovations in the surveyed companies. However, it is revealed that knowledge sharing has the greatest effect on the considered innovations in companies dealing with PV/T technologies. In addition, the lowest effect is obtained for the dimension of knowledge acquisition, while the effect of knowledge storage is medium.

• Book : (00)
• Pub. Date : 2025
• Page : pp.71-71
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Riedel’s thyroiditis is a rare inflammatory disease characterized by extensive fibrosis, often mimicking malignancy. The concurrent presence of Riedel’s thyroiditis with noninvasive follicular neoplasm with papillary-like nuclear features (NIFTP) is exceptionally rare and has not been previously reported. A 63-year-old male presented with an acute onset anterior cervical mass, fever, and dysphagia. Imaging revealed a large cystic mass in the right thyroid lobe extending into the mediastinum. Initial treatment with antibiotics led to partial improvement, but persistent swelling necessitated a deferred total thyroidectomy. Intraoperatively, the thyroid gland was fibrotic and adherent to surrounding structures. Histopathological examination confirmed Riedel’s thyroiditis with extrathyroidal extension and an underlying NIFTP. Postoperatively, the patient developed left vocal cord paresis and primary hypoparathyroidism. Systemic fibrotic involvement was ruled out through a thoracoabdominal-pelvic computed tomography (CT) scan. This case highlights the diagnostic challenges, atypical presentation, and management strategies of this unique coexistence, initially masquerading as a thyroid abscess.

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• Pub. Date : 2025
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• Book : 8(1)
• Pub. Date : 2025
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• Book : 5()
• Pub. Date : 2025
• Page : pp.100079-100079
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Background: Chest wall sarcoma is an uncommon condition, accounting for less than 5% of all thoracic neoplasms. It can arise frombone, cartilage, or soft tissues, depending on its tissue of origin. The most effective treatment approach is surgical resection with adequate margins. Recent research indicates that chemotherapy, whether administered as an adjuvant or neoadjuvant, may improve both overall survival and disease-free survival. This study focuses on examining common histological types, surgical approaches, post-surgical chemotherapy, reconstruction methods, and overall survival outcomes. Methods: Our study included patients who had undergone surgical management for chest wall sarcoma at our center since 2005 to 2020. Data from 39 consecutive patients were collected and entered into the Statistical Package for the Social Sciences (SPSS 16) for analysis. Results: Among 39 patients, the average age was 36 years, with 61% being male. 41% of patient presented delayed with mass size of >10 cm. While 46% underwent surgery alone, 54% received surgery combined with multimodal treatment (radiation and chemotherapy). The median survival was 89 months. Patients with low-grade sarcoma had a significantly better overall survival (Log rank, P<0.01). Although the Ewing’s sarcoma group had the poorest mean survival at 74 months, and the overall median survival could not be determined for this group, no statistically significant difference in overall survival was observed among sarcomas of different tissue origins. Conclusion: Chest wall sarcomas represent a varied group of tumors. In this study, chondrosarcoma and Ewing’s sarcoma were the most frequent types but exhibited the lowest survival rates, primarily due to high grade tumors at diagnosis. Effective management necessitates a multidisciplinary approach, including aggressive surgical resection to achieve R0 margins. Chest wall reconstruction should aim to restore structural and functional integrity with minimal complications. High-grade tumors are associated with poorer survival, that require multidisciplinary team approach.

• Book : 9(1)
• Pub. Date : 2025
• Page : pp.82-89
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Purpose This study aimed to evaluate long-term treatment outcomes in patients with localized gastric mucosa-associated lymphoid tissue (MALT) lymphoma treated with radiotherapy (RT).Materials and Methods A total of 229 patients who received RT in 10 tertiary hospitals between 2010 and 2019 were included in this multicenter analysis. Response after RT was based on esophagogastroduodenoscopy after RT. Locoregional relapse-free survival (LRFS) and disease-free survival (DFS), and overall survival (OS) were evaluated.Results After a median follow-up time of 93.2 months, 5-year LRFS, DFS, and OS rates were 92.8%, 90.4%, and 96.1%, respectively. LRFS, DFS, and OS rates at 10 years were 90.3%, 87.7%, and 92.8%, respectively. Of 229 patients, 228 patients (99.6%) achieved complete remission after RT. Five-year LRFS was significantly lower in patients with stage IIE than in those with stage IE (77.4% vs. 94.2%, p=0.047). Patients with age ≥ 60 had significantly lower LRFS than patients with age < 60 (89.3% vs. 95.1%, p=0.003). In the multivariate analysis, old age (≥ 60 years) was a poor prognostic factor for LRFS (hazard ratio, 3.72; confidence interval, 1.38 to 10.03; p=0.009). Grade 2 or higher gastritis was reported in 69 patients (30.1%). Secondary malignancies including gastric adenocarcinoma, malignant lymphoma, lung cancer, breast cancer, and prostate cancer were observed in 11 patients (4.8%) after RT.Conclusion Patients treated with RT for localized gastric MALT lymphoma showed favorable 10-year outcomes. Radiation therapy is an effective treatment without an increased risk of secondary cancer. The toxicity for RT to the stomach is not high.

• Book : 57(2)
• Pub. Date : 2025
• Page : pp.570-579
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• Book : 34()
• Pub. Date : 2025
• Page : pp.100749-100749
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Introduction: Neuroblastoma is the most common extracranial solid tumor in children, accounting for 8-10% of all pediatric cancers. Accurate diagnosis and management rely on imaging modalities and biological markers such as elevated urinary catecholamines. Among the various imaging techniques, Metaiodobenzylguanidine (MIBG) scintigraphy, often combined with SPECT/CT, provides high specificity for neuroblastoma cells. It is crucial for determining tumor extent, identifying metastatic disease, and monitoring therapeutic response. Materials and Methods: This study presents three clinical cases illustrating the role of MIBG scintigraphy in the diagnosis, staging, and follow-up of pediatric neuroblastoma. The three patients underwent Iodine-131 labeled MIBG scintigraphy, with planar imaging, and in two cases, additional SPECT/CT imaging. Results : Case 1: A 3-year-old child with a right adrenal mass and diffuse bone marrow metastases, classified as stage IV neuroblastoma. Case 2: An 11-year-old girl with recurrent retroperitoneal neuroblastoma identified during follow-up MIBG scintigraphy. Case 3: An 11-year-old girl with no evidence of disease progression, confirmed by MIBG scintigraphy, indicating complete remission. Conclusion: MIBG scintigraphy is an invaluable tool in the management of neuroblastoma, offering precise tumor localization, accurate staging, and effective monitoring of treatment response. Its integration into clinical practice helps guide therapeutic decisions and improves patient outcomes.

• Book : 17(1)
• Pub. Date : 2025
• Page : pp.1-8
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AbstractOrganelle dynamics and crosstalk play a critical role in cellular functions thereby regulating physiological processes and pathological conditions. A variety of cellular processes are outcome of a balance between organelle biogenesis and degradation. Pigmentation is one such homeostatic state that is a result of melanosome biogenesis and melanosome degradation. Although melanosome biogenesis is partially understood, the melanosome degradation i.e. melanophagy remains largely unappreciated. Here, we reveal that Inositol 1,4,5-trisphosphate receptor 2 (IP3R2) is a negative regulator of melanophagy. In this study, we developed twode novoratio metric imaging probes to study melanophagy in live-cells. Using these probes, biochemical assays, ultrastructural studies, confocal microscopy, molecular analyses and calcium imaging; we demonstrate that IP3R2, but not IP3R1 or IP3R3, keeps melanophagy in check.In vivostudies in zebrafish model system further substantiate IP3R2’s functional relevance in pigmentation. Mechanistically, IP3R2 silencing decreases mitochondrial Ca2+uptake, augments ADP/ATP ratio and thereby activates melanophagy. Simultaneously, IP3R2 knockdown increases ER-lysosome proximity, enhances lysosomal Ca2+levels and decreases lysosomal pH. This in turn activates lysosomal TRPML1 channel and stimulates nuclear translocation of TFEB transcription factor, which facilitates transcription of key autophagy and two known melanophagy drivers. Taken together, we uncover that IP3R2-mediated Ca2+signaling across organelles is a critical determinant of melanophagy and thereby skin pigmentation. Hence, this signaling cascade offers potential therapeutic prospects for the management of pigmentary disorders and skin malignancies.Highlights➢IP3R2, but not IP3R1 and IP3R3, is a critical positive regulator of melanogenesisin vitroandin vivo.➢Generation and validation of twode novoratio-metric live cells imaging probes reveal crucial role of IP3R2 in melanophagy.➢IP3R2 knockdown decreases mitochondrial Ca2+uptake, augments ADP/ATP ratio and thereby activates melanophagy via AMPK-ULK1 pathway.➢IP3R2 silencing enhances ER-lysosomal proximity, elevates lysosomal Ca2+levels and reduces lysosomal pH.➢IP3R2 knockdown stimulates lysosomal TRPML1 channel activity thereby facilitating nuclear translocation of TFEB transcription factor.➢TFEB transcriptionally upregulates genes involved in the melanophagy process, leading to enhanced degradation of melanosomes and decreased pigmentation.

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• Pub. Date : 2025
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AbstractBackgroundLittle is known about the prognostic value of plasma biomarkers in mild cognitive impairment with Lewy bodies (MCI‐LB).ObjectivesTo investigate the association of four plasma biomarkers with disease progression in MCI.MethodsPlasma amyloid‐beta (Aβ)42/40, glial fibrillary acidic protein (GFAP), neurofilament light (NfL), and phosphorylated tau 181 (pTau181) were measured at baseline in a longitudinal MCI cohort (n = 131).ResultsBaseline plasma NfL was associated with increased risk of dementia/death in the entire cohort. In MCI‐LB, baseline plasma NfL, GFAP, and pTau181 were associated with increased risk of dementia/death and increased cognitive decline measured by the Addenbrooke's Cognitive Examination‐Revised.ConclusionspTau181, GFAP, and NfL are associated with more rapid disease progression in MCI‐LB and, with further validation, could be useful to support prognosis and stratification for clinical practice and treatment trials. Further work, including clinicopathological studies, is needed to understand the biological correlates of these markers in MCI‐LB. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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• Pub. Date : 2025
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