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  • 2025

    Pelagia noctiluca blooms are a significant ecological event in the Mediterranean, with profound implications for marine ecosystems and coastal economies. This study aims to investigate the interannual and seasonal variability of Pelagia noctiluca bloom patterns along the Moroccan, Algerian, and Tunisian Mediterranean coasts, focusing on the influence of environmental factors such as sea surface temperature, nutrient availability, and oceanographic conditions on bloom intensity and distribution. The analysis reveals significant seasonal and interannual fluctuations in bloom size across the three regions, with the most substantial blooms occurring from June to August during the warmer months. In 2014 and 2018, peak bloom sizes of up to 775 jellyfish per unit area were recorded in Morocco and Algeria, while Tunisia also experienced notable blooms, particularly in 2015 and 2017. However, from 2020 to 2023, a marked decline in bloom intensity was observed across all three regions, with bloom sizes dropping, particularly in Tunisia and Morocco. Correlation analysis of environmental variables showed weak to moderate relationships between bloom size and key factors. Sea surface temperature showed a positive correlation (r = 0.13), suggesting that warmer waters contribute to increased bloom intensity. Nitrate and current direction also exhibited weak positive correlations (r = 0.12 and r = 0.27), indicating that nutrient availability and ocean circulation patterns could enhance bloom formation. The correlations with carbon (r = 0.08) and phosphate (r = 0.04) further suggest that organic matter and nutrient availability play a minor role in supporting bloom growth. On the other hand, negative correlations with factors such as oxygen (r = −0.04), solar radiation (r = −0.04), and wave height (r = −0.05) suggest that these factors may slightly inhibit bloom intensity, possibly by influencing nutrient dynamics and dispersing jellyfish populations. Notably, pH level (r = −0.29) and current speed (r = −0.23) exhibited stronger negative correlations, indicating a more pronounced inhibitory effect. In conclusion, this research highlights the complex and multifactorial nature of Pelagia noctiluca bloom dynamics, where temperature, nutrient availability, and oceanographic conditions interact to influence bloom size and distribution across the Moroccan, Algerian, and Tunisian coasts. While these environmental factors contribute to bloom variability, other ecological and anthropogenic factors likely play a significant role. Further research is necessary to better understand the synergistic effects of climate change, nutrient loading, and biological interactions on jellyfish bloom dynamics in the Mediterranean, with implications for effective management strategies.
    • Book : 13(4)
    • Pub. Date : 2025
    • Page : pp.642-642
    • Keyword :
  • 2025

    Cardiotoxicity represents a critical challenge in cancer therapy, particularly in the treatment of thoracic tumors, such as lung cancer and lymphomas, as well as breast cancer. These malignancies stand out for their high prevalence and the widespread use of cardiotoxic treatments, such as chemotherapy, radiotherapy, and immunotherapy. This work underscores the importance of preclinical models in uncovering the mechanisms of cardiotoxicity and developing targeted prevention and mitigation strategies. In vitro models provide valuable insights into cellular processes, enabling the observation of changes in cell viability and function following exposure to various drugs or ionizing radiation. Complementarily, in vivo animal models offer a broader perspective, allowing for evaluating of both short- and long-term effects and a better understanding of chronic toxicity and cardiac diseases. By integrating these approaches, researchers can identify potential mechanisms of cardiotoxicity and devise effective prevention strategies. This analysis highlights the central role of preclinical models in advancing knowledge of cardiotoxic effects associated with common therapeutic regimens for thoracic and breast cancers.
    • Book : 17(7)
    • Pub. Date : 2025
    • Page : pp.1059-1059
    • Keyword :
  • 2025


    • Book : 29(5)
    • Pub. Date : 2025
    • Page : pp.1-11
    • Keyword :
  • 2025

    본 논문은 폴리휴리스틱 모델(Poliheuristic Model)을 활용하여 러시아의 우크라이나 침공의 원인과 러시아의 국내 정책결정과정을 분석한 것이다.폴리휴리스틱 모델은 첫 번째 단계에서 ‘인지적 지름길’과 ‘비보상 원칙’을 적용하여 외교정책의 대안들을 선택하고, 두 번째 단계에서 이익 극대화와 손실 최소화라는 측면에서 합리적으로 대안들을 검토하여 최적의 정책 대안을 정하는 정책결정 모델을 의미한다.폴리휴리스틱 모델이라는 프리즘을 통해 우크라이나 침공을 바라보았을 때, 러시아는 1단계에서 NATO 확장에 대한 외교적 경고, 군사적 무력시위, 제한전쟁, 전면전쟁, 핵전쟁이라는 5가지 정책 옵션을 외교적, 경제적, 정치적, 군사적 수준에서 검토하였으며, 2단계에서 합리적 선택의 결과로 우크라이나에 대한 전면전쟁을 선택하였고, 제한전쟁을 우발계획으로 발전시켜 우크라이나 침공을 계획하였다.
    • Book : 14(1)
    • Pub. Date : 2025
    • Page : pp.51-76
    • Keyword :
  • 2025

    본 연구는 루스 워닥(Ruth Wodak)의 담화전략 이론을 기초로, 중국의 『인민일보』와 일본의 『아사히신문』에 실린 핵오염수 관련 기사를 분석 대상으로 하여, 양측 신문이 어떻게 네 가지 담화 전략을 운용하여 각각의 국가 이데올로기를 구현하는지에 대한 깊이 있는 탐구를 진행하였다.분석 결과는 다음과 같이 요약할 수 있다. 첫째, 명명전략에 있어서 『인민일보』는 『핵오염수』라는 용어를 사용하여 그 유해성을 강조하는 반면, 『아사히신문』은 『처리수라는 표현을 써서 그 무해성을 시사하는 경향을 보였다. 둘째, 서술전략에서 『인민일보』는 주로 소극적인 특징을 가진 동사들을 키워드와 유의미하게 결합시켰다면, 『아사히신문』은 소극적인 단어뿐만 아니라 적극적인 특징을 가진 형용사들도 키워드와 유의미하게 연계시켰다. 셋째, 논증 전략 측면에서 『인민일보』는 토포이(topoi)를 활용하여 해양 방류가 가져올 위험성, 일본 정부의 인권 침해, 무책임함 등을 논증한 반면, 『아사히신문』에서는 토포이를 이용한 논증이 거의 찾아볼 수 없었다. 넷째, 관점화 전략에서 『인민일보』는 주로 간접 인용을 통해 제3자의 반대 의견이나 국제법을 자주 인용하여 자신의 입장을 지지하는 반면, 『아사히신문』은 직접 인용을 통해 해양 방류에 대한 찬반 양측의 의견을 균형있게 제시하는 경향을 보였다. 이러한 담화 전략의 차이는 ALPS(다핵종제거설비)의 처리 결과, IAEA(국제원자력기구)의 심사 과정, 그리고 각 신문의 성격과 같은 사회적, 역사적 요인과 밀접한 관련이 있는 것으로 분석된다.
    • Pub. Date : 2025
    • Page : pp.59-88
    • Keyword :
  • 2025

    Intraocular metastases represent the most common type of intraocular tumors in adults. In most cases, the metastases originate from primary breast and lung cancers. Effective management of patients with intraocular metastatic disease requires a multidisciplinary approach involving ophthalmologists, oncologists, and radiation therapists. The primary goals of treatment are disease control, maintenance of optimal quality of life, and preservation of functional vision. This article provides an in-depth overview of intraocular metastases, with special emphasis on the practical aspects of their diagnosis and treatment based on the most recent literature.
    • Book : 17(6)
    • Pub. Date : 2025
    • Page : pp.1041-1041
    • Keyword :
  • 2025

    Karyopherins, carrier proteins that recognize particular cargo protein patterns known as nuclear localization signals (NLSs), mediate the nuclear translocation of big proteins. In order to better understand the process of nuclear transport of proteins and create the groundwork for the development of innovative treatments that specifically target importins, it is imperative to clarify the intricate interactions between nuclear transporters and their cargo proteins. Until recently, very few NLSs have been documented. In the current work, an in silico method was used to identify NLSs for importin 8. It was determined that the sequence RRKLPVGRS serves as a recognition motif for importin 8 binding a karyopherin that is involved in the nuclear transportation of several important proteins like AGOs, SMADs, RPL23A, and TFE3. The sequence was validated in vitro in the breast cancer cell line T47D. This work subscribes to the effort to clarify the intricate relationships between nuclear transporters and their cargo proteins, in order to better understand the mechanism of nuclear transport of proteins and lay the groundwork for the development of novel therapeutics that target particular importins and have an immediate translational impact.
    • Book : 26(6)
    • Pub. Date : 2025
    • Page : pp.2814-2814
    • Keyword :
  • 2025

    Abstract Radiation pressure is a key mechanism by which stellar feedback disrupts molecular clouds and drives H ii region expansion. This includes direct radiation pressure exerted by UV photons on dust grains, pressure associated with photoionization, and infrared (IR) radiation pressure on grains due to dust-reprocessed IR photons. We present a new method that combines high-resolution mid-IR luminosities from JWST-MIRI, optical attenuation, and nebular line measurements from the Very Large Telecope Multi-Unit Spectroscopic Explorer (VLT-MUSE), and the Hubble Space Telescope (HST) Hα-based region sizes to estimate the strength of radiation pressure in ≈18,000 H ii regions across 19 nearby star-forming galaxies. This is the most extensive and direct estimate of these terms beyond the Local Group to date. In the disks of galaxies, we find that the total reprocessed IR pressure is on average 5% of the direct UV radiation pressure. This fraction rises to 10% in galaxy centers. We expect reprocessed IR radiation pressure to dominate over UV radiation pressure in regions where L F2100W / L H α corr 75 . Radiation pressure due to H ionizations is lower than pressure on dust in our sample, but appears likely to dominate the radiation pressure budget in dwarf galaxies similar to the Small Magellanic Cloud. The contribution from all radiation pressure terms appears to be subdominant compared to thermal pressure from ionized gas, reinforcing the view that radiation pressure is most important in compact, heavily embedded, and young regions.
    • Book : 982(2)
    • Pub. Date : 2025
    • Page : pp.140-140
    • Keyword :
  • 2025

    With advances in space, nuclear, and defense industries, the susceptibility of semiconductor integrated circuits (ICs) to radiation has increased. Radiation-induced degradation and malfunctioning of IC performance can lead to system failure, leading to significant damage. To address this limitation, this study employed mixed-stage modeling and simulation (M&S) techniques to evaluate the reliability of complementary metal-oxide semiconductor application-specific ICs (ASICs) in radiation environments. Radiation-hardened IC chips were designed and fabricated using layout modification techniques based on M&S. The ASIC, which includes the D-latch and Operational Amplifier (Op-Amp) circuits, was validated for resistance up to a total ionizing dose of 20 kGy(Si). The proposed radiation-hardened ICs demonstrated stable performance even in radiation-exposed environments, ensuring reliable operation under such conditions. The findings provide insights into overcoming radiation-induced degradation and malfunction in semiconductor integrated circuits, which is particularly relevant for advancing space, nuclear, and defense industries.
    • Book : 14(7)
    • Pub. Date : 2025
    • Page : pp.1296-1296
    • Keyword :
  • 2025


    • Book : ()
    • Pub. Date : 2025
    • Page :
    • Keyword :