The present disclosure relates to a sgRNA and constructing a dual pig model of severe immunodeficiency and liver injury and use thereof. The method comprises the steps of knocking out RAG2, IL2Rγ and FAH genes in a porcine fetal fibroblast by using a CRISPR/Cas9 technology, constructing a RAG2−/−/IL2Rγ−/Y/FAH−/− triple-gene edited cloned pig by using a somatic cell nuclear transfer technology, and obtaining a dual pig model of severe immunodeficiency and liver injury through phenotypic analysis and identification. The method overcomes the problems of long production period, low efficiency, irreversible damage, unsatisfactory use in a humanization degree and the like in the existing model construction technology, can realize a batch construction of the dual pig model of severe immunodeficiency and liver injury by a continuous cloning technology, and has great advantages and potential market application prospects in the related fields of tumor biology, cell transplantation, humanized animal models and the like.

• 출원번호 : 18646802
• 출원인 : Wei, Hong-jiang
• 특허번호 :
• IPC : A01K-067/0276(2006.01);C07K-014/715(2006.01);C12N-009/22(2006.01);C12N-015/11(2006.01);C12N-015/90(2006.01);C12Q-001/6883(2006.01);

A method of making an electrode includes the step of mixing active material particles, radiation curable resin precursors, and electrically conductive particles to create an electrode precursor mixture. The electrode precursor mixture is electrostatically sprayed onto a current collector to provide an electrode preform. The electrode preform is heated and calendered to melt the resin precursor such that the resin precursor surrounds the active particles and electrically conductive particles. Radiation is applied to the electrode preform sufficient to cure the radiation curable resin precursors into resin.

• 출원번호 : 18647040
• 출원인 : DU, ZHIJIA
• 특허번호 :
• IPC : H01M-004/04(2006.01);H01M-004/1315(2010.01);H01M-004/1391(2010.01);H01M-004/13915(2010.01);H01M-004/1393(2010.01);H01M-004/1397(2010.01);H01M-004/62(2006.01);H01M-004/02(2006.01);

Described are structures and techniques for supporting a thermal radiation shield in a superconducting magnet. The thermal radiation shield can be supported off of a cold mass using low thermal conductivity structural supports. Structural supports, specifically thermal radiation shield supports and bumpers, may be installed between a cold mass and the radiation shield to mitigate deflections of the radiation shield. Thermal radiation shield supports are attached to both the cold mass and the radiation shield. Bumpers may be used in addition to thermal radiation shield supports and have a first end attached to either the cold mass or the thermal radiation shield and a second end not physically coupled to any structure.

• 출원번호 : US2024/026460
• 출원인 : MASSACHUSETTS INSTITUTE OF TECHNOLOGY;COMMONWEALTH FUSION SYSTEMS LLC;
• 특허번호 :
• IPC : H01F-006/04(2006.01);H01F-006/06(2006.01);G01R-033/3815(2006.01);

Provided is a method for producing a cotton-like freeze-dried nicotinamide mononucleotide (NMN) formulation that makes it possible to produce a cotton-like freeze-dried NMN formulation that can be prepared for use on site without any difficulties.　The method has: a solution preparation step for preparing a 5-200 mg/mL NMN solution; a dispensing step for dispensing the NMN solution, in an amount equivalent to 50 mg to 200 mg or 600 mg to 800 mg of NMN, into a vial to a depth of 10 mm to 45 mm; a freeze-drying step for carrying out, under pressure of 1 Pa to 100 Pa, a first process in which the vial is held at -37°C to -43°C for 8 hours, a second process in which the vial is held at -27°C to -33°C for 3 hours, a third process in which the vial is held at -12°C to -18°C for 99 hours, and a fourth process in which the vial is held at -3°C to 3°C for 6 hours, and a fifth treatment for raising the temperature to 27°C to 33°C, to generate cotton-like NMN; a gas phase formation step for filling a prescribed gas into the upper space of the vial; and a sterilization step for sterilizing the cotton-like NMN with radiation.

• 출원번호 : JP2024/016422
• 출원인 : SEED MEDICAL PHARMACEUTICAL CO., LTD.
• 특허번호 :
• IPC : A61K-031/706(2006.01);A61K-009/08(2006.01);A61K-009/19(2006.01);A61L-002/08(2006.01);A61P-003/02(2006.01);

Provided are a radiation-sensitive composition and a pattern formation method wherein sensitivity, CDU performance, and development defect suppression can be demonstrated at a sufficient level when next-generation technology is applied. [Solution] This radiation-sensitive composition includes: a polymer that includes a structural unit (I) represented by formula (1); a high-fluorine-content polymer that has a higher mass content of fluorine atoms than the aforementioned polymer; one or more types of onium salts including an organic acid anion and an onium cation; and a solvent, wherein at least some of the organic acid anions in the onium salt or salts include an iodine-substituted aromatic ring structure. (In formula (1), R is a hydrogen atom, a fluorine atom, a methyl group, or a trifluoromethyl group; Ar is an aromatic ring with 5-20 members and a valence of (p+q+r+1); R is a hydrogen atom or a C1-20 monovalent organic group; in cases in which a plurality of R moieties are present, the plurality of R moieties are the same as or different from each other; R is a cyano group, a nitro group, an alkyl group, a fluorinated alkyl group, or an acyl group; in cases in which a plurality of R moieties are present, the plurality of R moieties are the same as or different from each other; p and q are each independently an integer from 1 to 6; and r is an integer from 0 to 3.)

• 출원번호 : JP2024/016360
• 출원인 : JSR CORPORATION
• 특허번호 :
• IPC : G03F-007/039(2006.01);G03F-007/004(2006.01);G03F-007/20(2006.01);

The present disclosure relates to a radioactive polypeptide conjugate drug and for use thereof in nuclear medicine as a tracer, an imaging agent, and for treating various disease states associated with tumors is provided.

• 출원번호 : 18646785
• 출원인 : TIANJIN CONJUSTAR BIOLOGICS CO., LTD.
• 특허번호 :
• IPC : A61K-051/08(2006.01)

실시예는 원자로 내부 상태 예측 장치에서 수행되는 원자로 내부 상태 예측 방법은 원자로 노심의 측면의 서로 다른 높이에서 각각 측정된 복수의 누설 방사선량을 수집하는 단계, 상기 서로 다른 높이에서 각각 측정된 복수의 누설 방사선량을 이용하여 상기 원자로 내부의 냉각수 수위 정보를 예측하는 단계 및 상기 냉각수 수위 정보의 예측 결과, 상기 원자로 내부에 냉각수가 고갈되었다고 판단된 경우, 상기 서로 다른 높이에서 각각 측정된 복수의 누설 방사선량을 이용하여 상기 원자로 내부의 냉각수의 재충수 여부를 더 예측하는 단계를 포함한다.실시예는 누설 방사선량을 이용하여 원자로 내부의 상태를 예측함으로써, 원자력 발전소의 중대 사고를 방지할 수 있는 효과가 있다.

• 출원번호 : 10-2024-0055233
• 출원인 : 한국원자력연구원
• 특허번호 :
• IPC : G21C-017/022;G01T-001/16;G06Q-050/10;G21C-017/04;G21C-017/10;

This invention presents a method to improve the detect efficiency of sheet metal used as a radiation-electron converter by incorporating transverse holes into the metal surface. The pitch of these holes is deliberately smaller than the range of the photoelectrons. The resulting radiation detector is comprised of three main components: a converter, a collector array, and a readout circuit. The converter, featuring these strategic perforations, can be produced through various manufacturing processes such as electroforming using Anodic Aluminum Oxide (AAO) or patterned photoresist as a template, or it can be created using an etching-electroplating process suitable for certain metals. This innovative design offers multiple advantages, including high spatial resolution, increased detection efficiency, and lower production costs.

• 출원번호 : CA2024/050542
• 출원인 : TANG, Zheng Xiang
• 특허번호 :
• IPC : G01T-001/28(2006.01);G01T-001/29(2006.01);G01T-003/00(2006.01);

A metrology system is described. Metasurfaces are used to replace (or to augment) an existing demultiplexer to reduce the volume of the demultiplexer in the metrology system. A metasurface is configured to receive a diffracted radiation beam from a radiation source, and separate the beam into a narrower band sub-beam of radiation having a modified wavelength range, amplitude, pulse frequency, pulse time, polarization state or states, angular content, and/or spatial content in comparison to an incident wavelength range, amplitude, pulse frequency, pulse time, polarization state or states, angular content, and/or spatial content.

• 출원번호 : EP2024/061488
• 출원인 : ASML NETHERLANDS B.V.
• 특허번호 :
• IPC : G03F-009/00(2006.01);G03F-007/20(2006.01);G01N-021/956(2006.01);

Methods to form carbon coated particles are described. Methods to form coated particles involve subjecting the particles to an energy source that is at least one of hot gas, microwave energy, induction energy, direct current passing through the particles, electromagnetic radiation, or solar radiation, so as to form heated particles, and feeding a hydrocarbon source that is in the form of a gas or vapor into the chamber, such that the hydrocarbon source pyrolyzes, in at least in part, in the chamber to form carbon deposits, and thereby coating the heated base particles with the carbon deposits and form the carbon coated particles. Coated particles produced by one of the methods of the present invention is further described. The advantages achieved with the methods are further described.

• 출원번호 : US2024/026188
• 출원인 : CABOT CORPORATION
• 특허번호 :
• IPC : C01B-032/05(2017.01);C23C-016/26(2006.01);C01B-003/02(2006.01);