A radiation image capture apparatus including a plurality of pixels which include a detection pixel configured to detect an irradiation amount and an exposure decision unit configured to decide an amount of radiation irradiated from a radiation generation apparatus. The exposure decision unit decides the amount of irradiated radiation based on an output of the detection pixel during radiation irradiation and a correction value that is an output of the detection pixel while the radiation irradiation is not performed. The exposure decision unit obtains the correction value after a read operation of a signal based on radiation during image capture is performed, and in the subsequent image capture, the amount of irradiated radiation is decided based on the output of the detection pixel during the radiation irradiation and the correction value.

• 출원번호 : 18893623
• 출원인 : MORITA, HIDEAKI
• 특허번호 :
• IPC : G01T-001/29(2006.01);G01T-001/02(2006.01);G01T-001/17(2006.01);G01T-001/24(2006.01);G01T-007/00(2006.01);

Provided is a glutamic acid (Glu)-urea compound and a preparation method and use thereof. The Glu-urea compound and the nuclide-targeted probe have excellent in vivo biological properties and show a high specific uptake in lesions with high expression of a prostate-specific membrane antigen (PSMA) protein. The compound and probe have a high target/non-target ratio, low non-specific background activity, and significantly-enhanced tumor uptake and retention time. The compound and probe are suitable for use in the nuclide therapy and imaging of tumors, and can also reduce unnecessary radiation damage to normal tissues and organs. The compound and probe can also overcome the shortcomings such as low target organ uptake and short retention time of small-molecule PSMA, and improve the effects of PSMA-targeted nuclide therapy and imaging, thus exhibiting a potential to be widely used in clinical applications.

• 출원번호 : 18893474
• 출원인 : GUO, Zhide
• 특허번호 :
• IPC : A61K-051/08(2006.01);A61P-035/00(2006.01);

Compounds, compositions and methods are provided for the inhibition of ENPP1. Aspects of the subject methods include contacting a sample with an ENPP1 inhibitor compound to inhibit the cGAMP hydrolysis activity of ENPP1. In some cases, the ENPP1 inhibitor compound is cell impermeable. ENPP1 inhibitor compounds can act extracellularly to block the degradation of cGAMP. Also provided are pharmaceutical compositions and methods for treating cancer. Aspects of the methods include administering to a subject a therapeutically effective amount of an ENPP1 inhibitor to treat the subject for cancer. In certain cases, the cancer is a solid tumor cancer. Also provided are methods of administering radiation therapy to a subject in conjunction with administering an ENPP1 inhibitor to the subject. The radiation therapy can be administered in the subject methods at a dosage and/or frequency effective to reduce radiation damage to the subject, but still instigate an immune response.

• 출원번호 : 18893468
• 출원인 : Li, Lingyin
• 특허번호 :
• IPC : C07F-009/6512(2006.01);A61K-031/44(2006.01);A61K-031/4706(2006.01);A61K-031/517(2006.01);A61K-031/675(2006.01);A61K-031/69(2006.01);A61K-045/06(2006.01);A61P-035/00(2006.01);C07D-215/46(2006.01);C07D-401/04(2006.01);C07F-005/02(2006.01);C07F-009/60(2006.01);C07F-009/6558(2006.01);

An oxyhalide material of the present disclosure contains Li, M, O, and X. M is at least two selected from Group 5 elements. X is at least one selected from the group consisting of F, Cl, Br, and I. The oxyhalide material of the present disclosure shows a reversible oxidation-reduction reaction. In an X-ray diffraction pattern obtained by X-ray diffraction measurement on the oxyhalide material using Cu-Kα radiation, at least one peak is present in a first range, and (A) or (B) below is satisfied: (A) No peak is present in a second range. (B) At least one peak is present in the second range, and a ratio of intensity Ip1 of a peak with the highest intensity present in the first range to intensity Ip2 of a peak with the highest intensity present in the second range Ip1/Ip2 is larger than 5.

• 출원번호 : 18890830
• 출원인 : MIZUNO, KEITA
• 특허번호 :
• IPC : H01M-004/58(2006.01);H01M-004/02(2006.01);

A semiconductor device having a plurality of layers deposited on a substrate and extending in at least one lateral aspect defined by a lateral axis thereof comprises at least one EM radiation-absorbing layer deposited on a first layer surface and comprising a discontinuous layer of at least one particle structure comprising a deposited material. The at least one particle structure of the at least one EM radiation-absorbing layer facilitates absorption of EM radiation therein in at least a part of at least one of a visible spectrum and a UV spectrum while substantially allowing transmission of EM radiation therein in at least a part of at least one of an IR and an NIR spectrum.

• 출원번호 : 18892268
• 출원인 : OTI Lumionics, Inc.
• 특허번호 :
• IPC : H01Q-017/00(2006.01);G06F-003/044(2006.01);

A radiation reduction system that includes a computer and an imaging device configured to provide an image of a subject during a medical procedure using electromagnetic radiation. A variety of inputs are accepted from the medical practitioner using the computer such as subject body type, weight, and the like. These user inputs are used by the computer to determine operating settings that are transmitted to the imaging device either manually, a wired connection or wirelessly. The calculated settings are useful to generate one or more medically useful images of the subject while significantly reducing the overall radiation exposure to the subject and/or the personnel and/or medical practitioner.

• 출원번호 : 18891454
• 출원인 : Kingma, Phillip R.
• 특허번호 :
• IPC : A61B-006/00(2006.01);A61B-006/03(2006.01);G16H-010/60(2006.01);G16H-030/20(2006.01);G16H-040/40(2006.01);G16H-040/67(2006.01);G16H-070/20(2006.01);

A tiled interactive screen comprises a mounting surface and tiles mounted on the mounting surface. Each tile comprises a tile substrate with photoluminescent marks disposed in a pattern on or in the tile substrate. Each photoluminescent mark is unique with respect to every other photoluminescent mark on any of the tiles, each photoluminescent mark comprises a pattern encoding information specifying the location of the photoluminescent mark on the tile, and each tile substrate is at least partially transparent to light absorbed by the photoluminescent marks and is at least partially transparent to light emitted by the photoluminescent marks. The photoluminescent marks respond to stimulating electromagnetic radiation by emitting electromagnetic radiation. A tiled photonic interactive system comprises a tiled photonic interactive screen and an optical stylus operable to emit stimulating radiation onto one or more photoluminescent marks and respond to electromagnetic radiation emitted by the stimulated photoluminescent marks.

• 출원번호 : 18891982
• 출원인 : NANOGA SA
• 특허번호 :
• IPC : G06F-003/042(2006.01);G06F-003/03(2006.01);G06F-003/0354(2006.01);

The present disclosure provides a method of making an orthodontic article. The method includes (a) providing a photopolymerizable composition; (b) selectively curing the photopolymerizable composition using actinic radiation to form an article in the shape of an orthodontic article including a number of layers of at least one photopolymerized polymer; and (c) moving the article and thereby generating a mass inertial force in the uncured photopolymerizable composition. The article has a first surface, and no more than 75% of the first surface has a slope magnitude greater than 2.5 degrees. Orthodontic articles are also provided, including an orthodontic article that is prepared according to the method. Orthodontic articles having low extractable component content are further provided. The mass inertial force tends to form a coating layer of uncured photopolymerizable composition on the article, and curing the coating layer can form a surface having low slope magnitude. The low slope magnitude may be correlated to a low haze of the surface of the article.

• 출원번호 : 18891184
• 출원인 : Chakraborty, Saswata
• 특허번호 :
• IPC : A61C-007/08(2006.01);B29C-064/135(2006.01);B29C-064/241(2006.01);B29C-064/30(2006.01);B29C-071/02(2006.01);B29C-071/04(2006.01);B29L-031/00(2006.01);B33Y-010/00(2006.01);B33Y-040/20(2006.01);

A device for optimizing a radiation therapy plan (30) for delivering therapeutic radiation to a patient using a therapeutic radiation source (16) while modulated by a multi-leaf collimator (MLC) (14) includes at least one electronic processor (25) connected to a radiation therapy device (12). A non-transitory computer readable medium (26) stores instructions readable and executable by the at least one electronic processor to perform a radiation therapy plan optimization method (102) including: optimizing MLC settings of the MLC respective to an objective function wherein the MLC settings define MLC leaf tip positions for a plurality of rows of MLC leaf pairs at a plurality of control points (CPs). The optimizing is performed in two or more iterations with a resolution of the MLC settings increasing in successive iterations.

• 출원번호 : 18888511
• 출원인 : Neukirchen, Christoph
• 특허번호 :
• IPC : A61N-005/10(2006.01);G16H-020/40(2006.01);G16H-030/20(2006.01);

A control system includes a radiation emission apparatus and a radiographic imaging apparatus that generates image data by receiving radiation. A first apparatus of the radiation emission apparatus and the radiographic imaging apparatus includes a first timer that performs time measurement to periodically generate first time measurement information. A second apparatus of the radiation emission apparatus and the radiographic imaging apparatus includes a second timer that performs time measurement to periodically generate second time measurement information. The first apparatus includes an interface that transmits the first time measurement information to the second timer. At least one apparatus includes a hardware processor which adjusts the operation of the first or second timer based on adjustment conditions in a state where the second timer does not acquire the first time measurement information.

• 출원번호 : 18888498
• 출원인 : ISOGAI, Kohei
• 특허번호 :
• IPC : A61B-006/00(2006.01);A61B-006/42(2006.01);A61B-006/46(2006.01);G01T-001/17(2006.01);G01T-007/00(2006.01);G03B-042/02(2006.01);H05G-001/38(2006.01);