• Book : 1070(p1)
• Pub. Date : 2025
• Page : pp.170015
• Keyword :

Background: Iodine is often used as a contrast media because the k-shell binding energy (K-edge) is 33.2 keV, the average energy of a diagnostic X-ray. Thus, iodine can be utilized as a radiation attenuation material for X-rays. Objective: This study aimed to produce low-energy X-ray attenuation materials used as X-ray shielding. A sodium iodide compound will be synthesized by polymerizing mung bean starch with sodium iodide. Materials and methods: The iodide-starch-gel-based material (ISG) was made by mixing a mung bean starch solution (10 %w/w) with a sodium iodide (NaI) solution (100, 200, 250, and 300 mg-Iodine/gm). The linear attenuation coefficient (µ) was determined using radiation dose acquired from the DR plate system and CdTe detector. The X-rays were done at 50 - 120 kVp to study the attenuation properties. Results: The results showed that the linear attenuation coefficient of t ISG was slightly higher than that of sodium iodide solution at the same concentration. The spectrum still shows an X-ray absorption characteristic at about 30.1-40.5 keV K-edge range. Conclusion: Iodide-starch-gel-based components can attenuate X-ray with a K-edge range from 30-40 kVp. The attenuation coefficient of X-ray radiation varies linearly with energy level. Moreover, the concentration of the NaI solution is directly proportional to the attenuation of X-ray radiation. Thus, based on these properties and the gel-like consistency of the substance, it can be developed into a surface coating material to reduce X-ray radiation exposure.

• Book : 58(1)
• Pub. Date : 2025
• Page : pp.192-199
• Keyword :

• Book : 1070(p1)
• Pub. Date : 2025
• Page : pp.170016
• Keyword :

• Book : 860()
• Pub. Date : 2025
• Page : pp.139140
• Keyword :

• Book : 378(pa)
• Pub. Date : 2025
• Page : pp.124836
• Keyword :

• Book : 1053()
• Pub. Date : 2025
• Page : pp.122962
• Keyword :

• Book : 181()
• Pub. Date : 2025
• Page : pp.107347
• Keyword :

Abstract

Affordable, accurate, and robust temporal measurement devices are desirable for screening and assessment of radon levels in private homes and workplaces. This research expands upon prior research, using the RadonFTlab RadonEye device through a comparison of multiple samples of this instrument with a laboratory-grade instrument, the Saphymo AlphaGUARD, over a more extensive period than reported previously. Data were collected over 291 d in a poorly ventilated basement space in an occupied building. Environmental conditions varied naturally, changing both the radon source term and radon entry into the space approximating typically deployed conditions. The R-squared linear regression correlation coefficient and relative sensitivities of each RadonEye with the AlphaGUARD were computed. Overall temporal and diurnal variations were also studied. The sensitivities of all RadonEyes and the AlphaGUARD agreed to within 22% throughout the entire deployment period.

• Book : 128(1)
• Pub. Date : 2025
• Page : pp.60-65
• Keyword :

• Book : 559()
• Pub. Date : 2025
• Page : pp.165579
• Keyword :

The brain-related phenotypes observed in 22q11.2 deletion syndrome (DS) patients are highly variable, and their origin is poorly understood. Changes in brain metabolism might contribute to these phenotypes, as many of the deleted genes are involved in metabolic processes, but this is unknown. This study shows for the first time thatTbx1haploinsufficiency causes brain metabolic imbalance. We studied two mouse models of 22q11.2DS using mass spectrometry, nuclear magnetic resonance spectroscopy, and transcriptomics. We found thatTbx1^+/−mice andDf1/⁺mice, with a multigenic deletion that includesTbx1, have elevated brain methylmalonic acid, which is highly brain-toxic. Focusing onTbx1mutants, we found that they also have a more general brain metabolomic imbalance that affects key metabolic pathways, such as glutamine-glutamate and fatty acid metabolism. We provide transcriptomic evidence of a genotype-vitamin B12 treatment interaction. In addition, vitamin B12 treatment rescued a behavioural anomaly inTbx1^+/−mice. Further studies will be required to establish whether the specific metabolites affected byTbx1haploinsufficiency are potential biomarkers of brain disease status in 22q11.2DS patients.

• Book : 8(2)
• Pub. Date : 2025
• Page : pp.e202403075
• Keyword :