본문 바로가기

Report

All 3,287,370 Page 86/328,737

검색
  • 2025

    한국의 높은 핵무장 지지 여론은 어떻게 설명할 수 있을까? 핵무기와 국가 위상을 연관짓는 최근 여론 조사 결과와 대중과 엘리트 간 정보·인식 격차를 고려할 때, 기존 연구들이 집중해 온 북한 요인, 미국의 확장 억제, 경제 제재 외에 추가적인 설명 요인을 검토할 필요가 있다. 본 연구는 핵확산 문헌의 규범 모델을 바탕으로 국가 위상에 대한 고려가 핵무장 여론에 미치는 영향을 논의하고 가설을 제시하였다. 또한, 방사능 유출 위험성과 핵무장 소요 시간을 새로운 영향 요인으로 도출하고, 컨조인트 실험(conjoint experiment)을 활용하여 이 세 가지 요인과 안보 요인의 영향력을 비교하였다. 분석 결과, 국가 위상 이익인‘세계 핵클럽 가입’과 ‘군사 주권·외교 자주성 강화’는 핵무장 찬성 확률을 크게 증가시키고, 그 영향력은 핵심 안보 이익인 ‘북핵 위협 독자 억지’보다 더 큰 것으로 나타났다. 반면, ‘국제 규범 미준수로 인한 불량국가 낙인’과 ‘외교적 고립’이라는 국가 위상 비용, 그리고 ‘방사능 오염 위험성’은 안보 비용 요인으로 제시된 ‘일본의 핵무장 가능성 증가’보다 핵무장 찬성 확률을 더욱 큰 폭으로 감소시켰다. 본 연구는 대중과 전문가 간 핵무기·핵무장에 대한 인식 격차가 존재함을 보여주며, 현 국제 질서에서 핵무장의 실질적 결과에 대한 대중과의 소통 강화 및 핵 비확산 체제의 신뢰성 제고가 필요함을 시사한다.
    • Book : 17(1)
    • Pub. Date : 2025
    • Page : pp.143-195
    • Keyword :
  • 2025


    • Book : 34()
    • Pub. Date : 2025
    • Page : pp.100749-100749
    • Keyword :
  • 2025

    Introduction: Neuroblastoma is the most common extracranial solid tumor in children, accounting for 8-10% of all pediatric cancers. Accurate diagnosis and management rely on imaging modalities and biological markers such as elevated urinary catecholamines. Among the various imaging techniques, Metaiodobenzylguanidine (MIBG) scintigraphy, often combined with SPECT/CT, provides high specificity for neuroblastoma cells. It is crucial for determining tumor extent, identifying metastatic disease, and monitoring therapeutic response. Materials and Methods: This study presents three clinical cases illustrating the role of MIBG scintigraphy in the diagnosis, staging, and follow-up of pediatric neuroblastoma. The three patients underwent Iodine-131 labeled MIBG scintigraphy, with planar imaging, and in two cases, additional SPECT/CT imaging. Results : Case 1: A 3-year-old child with a right adrenal mass and diffuse bone marrow metastases, classified as stage IV neuroblastoma. Case 2: An 11-year-old girl with recurrent retroperitoneal neuroblastoma identified during follow-up MIBG scintigraphy. Case 3: An 11-year-old girl with no evidence of disease progression, confirmed by MIBG scintigraphy, indicating complete remission. Conclusion: MIBG scintigraphy is an invaluable tool in the management of neuroblastoma, offering precise tumor localization, accurate staging, and effective monitoring of treatment response. Its integration into clinical practice helps guide therapeutic decisions and improves patient outcomes.
    • Book : 17(1)
    • Pub. Date : 2025
    • Page : pp.1-8
    • Keyword :
  • 2025

    Haloarchaea, a group of extremophilic archaea, thrive in hypersaline environments characterized not only by high salinity but also by other extreme conditions, such as intense UV radiation, high osmotic pressure, heavy metal contamination, oxidative stress, and fluctuating temperatures. This study investigates the environmental adaptation strategies of species of two genera, Haloarcula and Natrinema, the second and third largest haloarchaeal genera, respectively, after Halorubrum. Comparative genomic analyses were conducted on 48 species from both genera to elucidate their genomic diversity, metabolic potential, and stress-tolerance mechanisms. The genomes revealed diverse metabolic pathways, including rhodopsin-mediated phototrophy, nitrogen assimilation, and thiamine biosynthesis, which support their survival and adaptation to extreme conditions. The analysis identified mechanisms for oxidative stress mitigation, DNA repair, “salt-in” and “salt-out” osmoregulatory strategies, adaptations to temperature shifts and heavy metal exposure, and immune defense. Experimental validation of four representative species, Haloarcula terrestris S1AR25-5AT, Haloarcula saliterrae S1CR25-12T, Haloarcula onubensis S3CR25-11T, and Natrinema salsiterrestre S1CR25-10T, isolated from the heavy-metal-rich hypersaline soils in the Odiel Saltmarshes (Huelva, Spain), demonstrated their tolerance, especially to arsenic, corroborating genomic predictions. This study advances our understanding of the resilience of haloarchaea under poly-extreme conditions and underscores their ecological significance and promise for biotechnological applications, such as the bioremediation of heavy-metal-polluted environments and the production of valuable biomolecules.
    • Book : 13(4)
    • Pub. Date : 2025
    • Page : pp.761-761
    • Keyword :
  • 2025

    ABSTRACTHIV-1 exploits host cell post-translation modifications (PTMs) to facilitate production of infectious particles. These modifications include SUMOylation, a dynamically regulated PTM involving covalent attachment of small ubiquitin-like modifiers (SUMOs) to lysine (K) residues of target proteins. SUMOylation modulates the activity of thousands of proteins and multiple fundamental host cellular processes, including pathways hijacked by HIV-1 to promote infection and spread. The SUMOylation of several proteins during HIV-1 infection has been characterized. However, the broad effects of HIV-1 infection on the SUMOylation of the host cell proteome is largely unknown. To date, SUMOylation has not been explored by large-scale proteomics in the context of HIV infection, where many SUMO-regulated host dependency factors remain to be identified. In this study, we performed a proteome-wide, mass spectrometry (MS)-based screen to identify proteins that are SUMOylated during HIV-1 infection. Here, and in immunoprecipitation assays, infection with HIV-1 led to the widespread increased SUMOylation of heterogeneous nuclear ribonucleoprotein (HNRNP) A/B family members. We selected HNRNPA2B1 (A2/B1) and HNRNPA3 for further study. We find that infection with HIV-1 specifically induced the SUMOylation of both proteins by SUMO1 and SUMO2 paralogs in multiple biochemical assays and in multiple human cell lines. Current efforts include generating non-SUMOylatable HNRNPA2B1 and HNRNPA3 mutants to test the functional consequences of their SUMOylation on the splicing of HIV-1 mRNAs. Together, our data point to a novel mechanism involving HIV-1-induced SUMOylation of these host RNA splicing factors as a means to regulate HIV-1 splice variant production. Broadly, our findings suggest that infection with HIV-1 alters the SUMOylation of many unexplored host cellular proteins, and provides a proteomic resource for their future mechanistic study.
    • Book : ()
    • Pub. Date : 2025
    • Page :
    • Keyword :
  • 2025


    • Book : ()
    • Pub. Date : 2025
    • Page :
    • Keyword :
  • 2025

    For the traditional physical model of the quantum quartic anharmonic oscillator with the Hamiltonian H = ½(p2 + x2) + λx4, which plays a significant role in quantum field theory, elementary particle physics, and nuclear physics, its physical characteristics and properties are comprehensively studied and calculated. The method we propose for studying the model, based on expanding the system's wave function in a complete set of harmonic oscillator eigenfunctions, facilitates a thorough analysis and evaluation of all parameters and features of the corresponding quantum systems. This model is also widely used for studying molecular vibrations, phonon modes in solids, nonlinear optical phenomena, and more. We have calculated and constructed the wave functions of the anharmonic oscillator for various values of the oscillator coupling constant λ. Furthermore, an improved and modified expansion method, using a generalized optimizing oscillator basis with variable frequency, has also been proposed and studied in detail. This improved method drastically accelerates the convergence of expansions across the entire range of the coupling constant variation, thereby substantially increasing the efficiency of the applied method by allowing calculations with a very small number of expansion basis functions N ≲ 10. Consequently, this modified approach provides a practically complete, quite simple, and efficient solution to the problem of the quartic anharmonic oscillator, enabling the relatively easy computation of all its physical properties, including the energies of the ground and excited states, as well as the wave functions of these states, for any values of the coupling constant.
    • Book : 26(1)
    • Pub. Date : 2025
    • Page : pp.5-24
    • Keyword :
  • 2025


    • Book : ()
    • Pub. Date : 2025
    • Page : pp.101773-101773
    • Keyword :
  • 2025


    • Book : ()
    • Pub. Date : 2025
    • Page :
    • Keyword :
  • 2025


    • Book : ()
    • Pub. Date : 2025
    • Page : pp.101804-101804
    • Keyword :