We report a case of a 73-year-old man with minimally invasive lung adenocarcinoma, post-resection, evaluated with 18F-FDG PET/CT for suspected disease progression. Imaging showed increased FDG uptake in the right lower lung mass and systemic lymphadenopathy (mediastinal, supraclavicular, axillary, paraaortic, and iliac regions). The appearance of a stable lymph node and a clinical history of IgG4 lymphadenopathy suggested an inflammatory process, although malignancy in the lung mass and mediastinal nodes could not be excluded. Lobectomy confirmed the presence of lung adenocarcinoma, while radical lymph node dissection identified IgG4-related lymphadenopathy without metastasis. This case underscores the need for considering differential diagnosis of PET-positive lymphadenopathy, especially in patients with comorbid conditions that mimic or coexist with malignancy.

• Book : 15(1)
• Pub. Date : 2025
• Page : pp.41
• Keyword :

Abstract

A longer pulse, lower adiabat drive in a low gas-fill hohlraum is an inertial confinement fusion design with potential higher gain, but has challenges such as the less tamped wall plasma. Thus, it is necessary to alter the laser spot regions to control low-mode drive asymmetry when using such laser pulses. The hollow wall is designed [Vandenboomgaerde et al 2018 Phys. Plasmas 25 012713] and has been demonstrated with experiments to be effective in holding back the gold bubble expansion [Depierreux et al 2020 Phys. Rev. Lett. 125 255 002]. This paper presents experimental and simulation results demonstrating that hollow wall hohlraums effectively reduce laser spot motion. Experiment results indicate that the laser spot position in hollow wall hohlraum moves less than that in classical solid hohlraum, similar data are obtained by 2D simulation. This reduction in motion is beneficial for improving P4 drive asymmetry.

• Book : 65(2)
• Pub. Date : 2025
• Page : pp.026018
• Keyword :

ABSTRACT

Vaccines are the most effective tool against COVID‐19 and are generally safe. Very rare and heterogeneous cases of acute liver injury associated to all types of SARS‐CoV‐2 vaccines have been reported, mostly with autoimmune features. Epidemiological studies used heterogeneous diagnostic criteria and included different populations. Immunological studies in selected cases of acute liver injury linked to mRNA SARS‐CoV‐2 vaccines suggest that it has a unique pathophysiology, the vaccine‐encoded spike protein playing a central role in triggering the aberrant immune response. In most series, liver injury was observed more often following the second vaccine dose. Latency from vaccination to the diagnosis of hepatitis was 1-147 days after the last vaccine dose. Raised immunoglobulin G levels and positive anti‐nuclear and/or anti‐smooth muscle antibodies are frequent. The vast majority of reported cases have been treated with corticosteroids, mostly associated with azathioprine. Outcome is generally favourable, but cases requiring liver transplantation or causing death have been reported. The heterogeneous clinical entity of acute liver injury linked to SARS‐CoV‐2 vaccines includes patients requiring long‐term immunosuppression, similarly to autoimmune hepatitis, and patients with self‐limiting liver damage, possibly representing a unique form of autoimmune‐like hepatitis, which we suggest being referred to as SARS‐CoV‐2 vaccine‐associated liver injury (SVALI). Further studies are needed to investigate the pathogenic mechanisms related to the immune response to the spike viral protein in the liver.

• Book : 45(1)
• Pub. Date : 2025
• Page : pp.e16209
• Keyword :

Radiotherapy is a critical treatment for cancer but poses significant risks to ovarian tissue, particularly in young females, leading to premature ovarian failure (POF). This study examines the therapeutic potential of etoricoxib nanostructured lipid carriers (ETO-NLC) in mitigating radiation-induced ovarian damage in female Wistar rats. Twenty-four female rats were randomly assigned to four groups: a control group receiving normal saline, a group exposed to a single dose of whole-body gamma radiation (6 Gy), a group treated with etoricoxib (10 mg/kg) post-radiation, and a group treated with ETO-NLC for 14 days following radiation. Histopathological evaluations and oxidative stress biomarker assessments were conducted, including ELISAs for reactive oxygen species (ROS), pro-inflammatory cytokines (IL-1β, TNF-α), and signaling molecules (PI3K, AKT, P38MAPK, AMH). Serum levels of estrogen, FSH, and LH were measured, and gene expression analysis for TGF-β and Nrf2 was performed using qRT-PCR. The findings indicate that ETO-NLC has the potential to ameliorate the harmful effects of ovarian damage induced by γ-radiation. These therapeutic effects were achieved through the modulation of oxidative stress, inflammation, augmentation of antioxidant defenses (including Nrf2 activation), support for cell survival pathways (via PI3K/Akt signaling), regulation of MAPK, mitigation of fibrosis (TGF-β), and preservation of ovarian reserve (as evidenced by AMH, FSH/LH, and estrogen levels). ETO-NLC shows promise as an effective strategy for attenuating radiation-induced ovarian damage, highlighting the need for further research to enhance therapeutic interventions aimed at preserving ovarian function during cancer treatment.

• Book : 15(1)
• Pub. Date : 2025
• Page : pp.12
• Keyword :

Prostate cancer (PCa) is a high-prevalence disease usually characterized by metastatic spread to the pelvic lymph nodes and bones and the development of visceral metastases only in the late stages of disease. Positron Emission Tomography (PET) plays a key role in the detection of PCa metastases. Several PET radiotracers are used in PCa patients according to the stage and pathological features of the disease, in particular 68Ga/18F-prostate-specific membrane antigen (PSMA) ligands. Moreover, 2-deoxy-2-[18F]fluoro-D-glucose 18F-FDG PET usually shows metastases in the late stages of disease, when dedifferentiated neoplastic clones lose PSMA expression. In some cases, PCa patients may present atypical sites of metastases, with uncommon appearance at PET imaging with different radiotracers. We present the case of a patient with biochemical recurrence of PCa (ISUP Grade Group IV; PSA 4.7 ng/mL) showing atypical sites of metastases (the testis and multiple lung nodules) with absent PSMA expression and high [18F]FDG avidity. The patient showed diffuse positivity to alpha-methylacyl-coenzyme A racemase (AMACR). Moreover, a literature review was performed by collecting cases of PCa patients with atypical metastatic spread detected via PET imaging, with the aim of highlighting the relationship between atypical sites of metastases, imaging presentation, and pathology findings.

• Book : 15(1)
• Pub. Date : 2025
• Page : pp.17
• Keyword :

This investigation attempts to estimate time-averaged shear wave velocity in the upper 30 m of surficial material, VS30, from the horizontal-to-vertical spectral ratios, HVSRs, of seismic observatory stations in the South Korean region. From 2016 to 2023, a collection of 783 three-component ground motions were obtained from 19 stations operated by the Korea Institute of Geoscience and Mineral Resources. HVSRs were extracted from 5% damped acceleration and velocity RotD50 response spectra at each site. Peak HVSR frequencies and amplitudes were extracted and regressed to field-measured VS30s at available sites. An evaluation of different frequency and amplitude conditions was made to ascertain any effects on the regression. Findings included confirmation on minimum frequency and having amplitude conditions were unnecessary. Additionally, another peak frequency to VS30 relationship derived from Central and Eastern North America captured most of the behavior found in the Korean dataset.

• Book : 15(1)
• Pub. Date : 2025
• Page : pp.214
• Keyword :

• Book : 1072()
• Pub. Date : 2025
• Page : pp.170160
• Keyword :

• Book : 34()
• Pub. Date : 2025
• Page : pp.2253-2259
• Keyword :

Coronary heart disease (CHD) is the leading cause of morbidity and mortality worldwide despite significant improvements in diagnostic modalities. Emerging evidence suggests that erythrocytes, or red blood cells (RBCs), are one of the most important contributors to the events implicated in atherosclerosis, although the molecular mechanisms behind it are under investigation. We used NMR-based lipidomic technology to investigate the RBC lipidome in patients with CHD compared to those with normal coronary arteries (NCAs), all angiographically documented, and its correlation with coronary artery stenosis. Targeted and untargeted lipidomic analysis revealed that CHD patients presented significant lipid alterations in the RBC membrane, characterized by higher cholesterol, sphingolipids, saturated and monounsaturated fatty acids, lower phospholipids (glycerophospholipids and ether glycerolipids), and unsaturated and polyunsaturated fatty acids. These aberrations gradually distinguish the three subgroups of patients with mild, moderate, and severe coronary stenosis, potentially indicating their non-negligible involvement in the onset and progression of atherosclerosis. The comprehensive analysis of RBC-membrane-derived lipids with omics approaches could unravel specific lipid abnormalities taking place at the silent subclinical stage of atherosclerosis and could have the potential to identify patients with subtle, but still proatherogenic, abnormalities that may confer a higher risk for the development of CHD.

• Book : 30(1)
• Pub. Date : 2025
• Page : pp.36
• Keyword :

Abstract

Can a naked singularity (NkS) be distinguished from a black hole (BH)? We have investigated it with cutting-edge general relativistic magnetohydrodynamic simulations, followed by general relativistic radiation transfer calculation for magnetized accretion flow around NkS and BHs. Based on our simulations, the accreting matter close enough to the singularity repels due to effective potential. This prevents matter from reaching an NkS and forms a quasi-spherical symmetric density distribution around it, unlike the accretion flows around a BH. We observe 1 order of magnitude higher mass flux through the jet and much stronger wind from an NkS than a BH. We found that the jet launching mechanism in an NkS differs significantly from that in a BH. In the horizon-scale images, an NkS shows a photon arc instead of a photon ring that is shown around a BH. In summary, the flow dynamics and radiative properties around an NkS are distinctly different from a BH. These properties would be useful to either confirm or rule out such exotic compact objects through future observations.

• Book : 978(1)
• Pub. Date : 2025
• Page : pp.44
• Keyword :