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2025
MR-guided radiotherapy (MRgRT) is novel treatment modality in Radiation Oncology that could allow a higher precision and tolerability of Radiation Treatments. This modality is possible due to dedicated systems consisting of a MR scanner mounted on a conventional linac and software that permit daily online treatment plan adaptation. Prostate cancer (PC) is one of the most common malignancies in RO clinical practice and currently under investigation with this new technology. The focus of this review is to describe the current state of the art and clinical results of MRgRT in the treatment of PC. The available technology are briefly described, as well as the published literature and possible future applications - Book : 24()
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2025
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2025
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2025
The relativistic jets of gamma-ray bursts (GRBs) might be powered by a black-hole (BH) hyperaccretion system. The inherent asymmetry in these jets generates recoil forces, inducing oscillations and positional deviations of the BH from equilibrium. In this study, we explore the influence of different initial BH mass, spin, and mass accretion rate, as well as their evolutions on the dynamical properties of BH under the effect of asymmetric jets. Our results reveal that the initial mass and accretion rate significantly impact the BH’s acceleration, velocity, and displacement, while the different initial spin plays a negligible role in shaping the overall dynamical evolution. Additionally, we calculate the gravitational wave (GW) strains associated with the asymmetric jets, finding that the resulting GW signals are too weak to be detected, even for nearby GRBs. These findings provide critical insights into the dynamical response of BHs to asymmetric jets and the associated GW radiation, advancing our understanding of BH physics in GRBs.- Book : 11(2)
- Pub. Date : 2025
- Page : pp.43-43
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2025
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- Pub. Date : 2025
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2025
Axion-like particles (ALPs) are hypothetical pseudoscalar bosons, natural in extensions of the Standard Model. Their interactions with ordinary matter and radiation are suppressed, making it challenging to detect them in laboratory experiments. However, these particles, produced within stellar interiors, can provide an additional mechanism for energy loss, potentially influencing stellar evolution. Prominent methods for searching for such effects involve measuring the properties of red giants and helium-burning stars in globular clusters (GCs). Here we use published catalogs of stars selected as members of seven GCs on the basis of parallaxes and proper motions measured by Gaia (Data Release 3). Making use of previously derived theoretical relations and the new data, we find the upper limit on the ALP-electron coupling, g
ae
< 5.2 × 10–14 (95% CL), and an indication (3.3σ) to nonzero ALP-photon coupling, g
aγ =
$$(6.5_{{ - 1.3}}^{{ + 1.1}})$$
× 10–11 GeV–1. Given the precision of contemporary observational data, it is imperative to refine ALP constraints through more sophisticated analyses, which will be explored in detail elsewhere.- Book : ()
- Pub. Date : 2025
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2025
- Book : 42()
- Pub. Date : 2025
- Page : pp.101880-101880
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2025
Lycopene which is a carotenoid found in tomatoes and other red and orange fruits, has shown benefits in dermatology and photoprotection. It is a powerful antioxidant and has been proposed as a potential ingredient for sunscreen preparations designed to reduce UV-induced skin damage. The review will discuss the available data regarding the activity of lycopene in sunscreen formulations, mainly in relation to mechanism of action, performance.
The photoprotective properties of lycopene depend on its free radical scavenger activity and capacity for neutralizing ROS, produced upon UV activation. ROS plays a key role in damage to structures within skin through DNA mutations, inflammation, photo-ageing, and enhanced risk for skin cancer. Lycopene has antioxidant properties and the capacity to absorb UV radiation in the UVA and UVB spectrum, making it an interesting ingredient in fortified sunscreens. Several in vitro and in vivo studies have shown that lycopene can significantly reduce erythema, DNA damage, and oxidative stress after UV exposure, making it an interesting potential preventive agent against both acute sunburn and chronic, cumulative damage associated with long-term skin ageing.
Lycopene remains a highly promising natural photoprotective agent; however, additional clinical studies and safety assessments must be undertaken to establish the best use of lycopene as a participant in the composition of sunscreen ingredients- Book : ()
- Pub. Date : 2025
- Page : pp.618-626
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2025
Special AT-rich sequence-binding protein 2 (SATB2), as a nuclear matrix-associated protein and transcription factor engaged in chromatin remodeling and the regulation of gene expression, plays an important role in growth and development processes. SATB2 has been shown to have tissue-specific expression, also related to some cancers, including colorectal cancer (CRC). The aim of this study was to compare SATB2 gene expression in tumor and matched non-involved colorectal tissues obtained from CRC patients, and to investigate its association with clinicopathological and demographic parameters, as well as patients’ overall survival. SATB2 mRNA levels in the tested tissues were assessed by quantitative polymerase chain reaction, while SATB2 protein expression was determined by immunohistochemistry. We found that the average levels of both SATB2 mRNA and protein were significantly lower in tumor specimens than in matched non-involved colon tissues. Moreover, SATB2 immunoreactivity was associated with patients’ sex, tumor localization, and grade of differentiation. Lower immunoreactivity of SATB2 protein was noted in high-grade tumors, in women, and in tumors located in the cecum, ascending, and transverse colon. However, the results of the present study did not show an association between SATB2 expression levels and patients’ overall survival. Our findings indicate the involvement of impaired SATB2 expression, significantly reduced in high-grading tumors, in the pathogenesis of CRC, while its sex- and localization-specificity should be further elucidated.- Book : 26(5)
- Pub. Date : 2025
- Page : pp.2374-2374
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2025
- Book : 217()
- Pub. Date : 2025
- Page : pp.111253-111253
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