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2025
Using 20.3 fb−1 of e+e− collision data collected at the center-of-mass energy 3.773 GeV with the BESIII detector, we report the first observation of the semileptonic decay D+→η′μ+νμ with significance of 8.6σ including systematic uncertainties, and an improved measurement of D+→η′e+νe. The branching fractions of D+→η′μ+νμ and D+→η′e+νe are determined to be (1.92±0.28stat±0.08syst)×10−4 and (1.79±0.19stat±0.07syst)×10−4, respectively. The ratio of the two branching fractions is determined to be Rμ/e=1.07±0.19stat±0.03syst, which agrees with the theoretical expectation of lepton flavor universality within the standard model. From an analysis of the D+→η′ℓ+νℓ decay dynamics, the product of the hadronic form factor f+η′(0) and the Cabibbo-Kobayashi-Maskawa matrix element |Vcd| is measured for the first time, giving f+η′(0)|Vcd|=(5.92±0.56stat±0.13syst)×10−2. The η−η′ mixing angle in the quark flavor basis is determined to be ϕP=(39.8±0.8stat±0.3syst)°.
Published by the American Physical Society
2025
- Book : 134(11)
- Pub. Date : 2025
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2025
Invasive species are organisms that enter an ecosystem as a result of anthropological activities. These species compete with native species in the environment where they settle, threatening the ecological structure and changing biodiversity. Grateloupia turuturu, known as an invasive species, was reported for the first time in May 2015 from the coast of Bandırma in Turkey and it was determined that it is now distributed in Erdek and Mudanya coasts. In general, invasive species are known to have a wide tolerance to ecological variables. Therefore, the aim of this study was to determine the physiological effects of UVR on G. turuturu species and to investigate the responses of G. turuturu species to UVR. For this purpose, G. turuturu samples were cultured in 3 different light regimes (photosynthetically active radiation, UVA and UVB) and their physiological responses were investigated. The data obtained showed that the photosynthetic activity and nitrate reductase enzyme activities of the samples exposed to UVR increased, whereas the accessory pigment content did not change. In conclusion, G. turuturu is able to utilize UVA energy as light sources in photosynthesis and is tolerant but not sensitive to UVR. Therefore, it is thought that G. turuturu may be advantageous in competition with local species.- Book : 8(2)
- Pub. Date : 2025
- Page : pp.120-129
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2025
Abstract
We present a study of giant molecular cloud (GMC) properties in the Andromeda galaxy (M31) using CO(3-2) data from the James Clerk Maxwell Telescope (JCMT) in selected regions across the disc and in the nuclear ring, and comparing them with CO(1-0) observations from the IRAM 30m telescope in the same regions. We find that GMCs in the centre of M31 generally exhibit larger velocity dispersions (σ) and sizes (R) compared to those in the disc, while their average surface density (Σ) and turbulent pressure (Pturb) are lower. This low turbulent pressure in the central region is primarily due to the low density of molecular gas. The estimated GMC properties depend on the choice of CO transitions. Compared to CO(1-0), CO(3-2) exhibits smaller velocity dispersion and equivalent radius but higher surface density. These differences highlight the distinct physical conditions probed by different molecular gas tracers. We estimate the virial parameter αvir∝σ2R/Σ and find that most molecular clouds exhibit high values (αvir ∼ 4 − 6) for both CO transitions, indicating that they are unbound. Furthermore, clouds in the nuclear ring display even larger αvir values of ≲ 100, suggesting that they may be highly dynamic, short-lived structures, although they could potentially achieve equilibrium under the external pressure exerted by the surrounding interstellar medium.- Book : ()
- Pub. Date : 2025
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2025
AbstractSolar radiation modification (SRM) reflects sunlight back into space and could rapidly cool Earth, potentially reducing the harms of dangerous climate change. Current international law fails to directly and comprehensively address the transboundary, regional and global governance challenges that SRM presents. Various ideas for governance have emerged, drawing on multiple areas of existing law. This article offers a critical review of the existing space law literature and analyses its applicability to SRM governance. First, space law would ‘directly’ apply to space‐based SRM proposals such as a large satellite sunshade. Second, this paper argues that space law could ‘indirectly’ contribute to SRM governance, in that space activities and their governance can provide useful insights for future SRM governance. This article pushes for a deeper investigation of space law to inform future SRM governance.- Book : ()
- Pub. Date : 2025
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2025
The Artemis missions will establish a sustainable human presence on the Moon, serving as a crucial steppingstone for future Mars exploration. Astronauts on these ambitious missions will have to successfully complete complex tasks, which will frequently involve rapid and effective decision making under unfamiliar or high-pressure conditions. Exposure to low doses of space radiation (SR) can impair key executive functions critical to decision making. This study examined the effects of exposure to 10 cGy of Galactic Cosmic Ray simulated radiation (GCRsim) on decision-making performance in male and female rats with a naturally low predisposition for risk-taking (RTP) prior to exposure. Rats were assessed at monthly intervals following SR exposure and the RTP performance contrasted with that observed during the prescreening process. Exposure to 10 cGy of GCRsim impaired decision making in both male and female rats, with sex-dependent outcomes. By 30 days after SR exposure, female rats became more risk-prone, making less profitable decisions, while male rats retained their decision-making strategies but took significantly longer to make selections. However, continued practice in the RTP tasks appeared to reduce/reverse these performance deficits. This study has expanded our understanding of the range of cognitive processes impacted by SR to include decision making.- Book : 15(3)
- Pub. Date : 2025
- Page : pp.449-449
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2025
The Biofilm Onboard Radiation Exposure Assessment Lab In Space (BOREALIS) mission is a 6U CubeSat initiative funded by the Italian Space Agency under the ALCOR program, executed through a collaboration among the School of Aerospace Engineering of Sapienza University of Rome, Interdepartmental Centre for Industrial Aerospace Research (CIRI Aerospace) of the University of Bologna and Kayser Italia Srl. BOREALIS is equipped with a lab-on-chip payload for studying the effects of microgravity and ionising radiation on microbial biofilms, which are crucial for understanding and preventing persistent infections in space environments. The satellite will operate across multiple orbits, moving from low to medium Earth orbit, to distinctly analyse the impacts of radiation separate from microgravity. The required orbital transfer not only tests the autonomy of its on-board systems in challenging conditions but also places BOREALIS among the first and few CubeSats to have ever attempted such a complex manoeuvre. This study explores the systematic application of Model-Based Systems Engineering to satellite design, from conceptualisation to trade-offs, using a tradespace analysis approach supported by Monte Carlo simulations to optimise mission configurations against performance and cost. Additionally, the adaptability of Model-Based Systems Engineering tools and the reusability of such an approach for other satellite projects are discussed, illustrating the BOREALIS mission as a case study for small mission design considering constraints and requirements.- Book : 12(3)
- Pub. Date : 2025
- Page : pp.256-256
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2025
Industrial waste management is a growing concern, and the valorization of by-products through circular economy approaches represents a sustainable solution. In this context, dextran–grape conjugates (PLG–GRAPE) were obtained via a grafting reaction of grape pomace extract and dextran under aqueous conditions. To compare the properties of the polymeric graft with those of the free extract, total polyphenol content was assessed using the Folin–Ciocalteu assay, along with stability and diffusion studies. In addition, in vitro safety evaluations, including Neutral Red Uptake, h-CLAT, and skin irritation tests were performed to assess the biocompatibility. To evaluate the antioxidant, anti-inflammatory, and anti-aging properties of PLG–GRAPE, in vitro efficacy assays were performed on keratinocyte and fibroblast cell lines and full-thickness reconstructed human tissues exposed to damaging agents, such as UV radiation and pollutants. The results showed that the technology preserved the phenolic and antioxidant activity of the extract, while improving diffusion and stability properties. As demonstrated by the results of the in vitro studies, a favorable biocompatibility profile was observed, in addition to a significant capacity to reduce oxidative stress and inflammation in aged cells, thus, attenuating cellular aging and senescence. In conclusion, the study suggests that PLG–GRAPE has potential as a bioactive ingredient for cosmetic and dermatological applications, offering a sustainable and effective approach to utilizing industrial waste products.- Book : 15(6)
- Pub. Date : 2025
- Page : pp.3220-3220
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2025
Introduction COVID-19, caused by SARS-CoV-2, has raised concerns about its potential to trigger autoimmune phenomena and post-infection autoimmune diseases. This study aimed to assess the prevalence and patterns of antinuclear antibodies (ANA) in post COVID-19 patients. Methods A cross-sectional study was conducted from August to October 2021, involving 108 adult post COVID-19 patients with articular and musculoskeletal symptoms. ANA screening was performed using the Indirect Immunofluorescent Test (IIFT) with HEp-2 cell substrate, and positive samples were further analyzed using Line ImmunoAssay (LIA) for specific ANA detection. Demographic data and disease severity information were collected. Results Among the participants, 29% tested positive for ANA by IIFT, and 17% of those with 3 months post COVID-19 and 37% with >6 months post COVID-19 were ANA-positive. LIA confirmed ANA positivity in 18 patients. The most common ANA pattern was nuclear speckled (52%), followed by homogenous (21%), DFS 70, and Nucleolar (10% each), and Cytoplasmic (7%). The prevalence of ANA increased significantly with longer post COVID-19 duration (>6 months vs. 3 months, p = 0.017) U1 snRNP-related speckled pattern was most frequent. However, the study found no correlation between ANA patterns and post COVID-19 duration. Conclusion The findings suggest that COVID-19 may trigger the development of ANA autoantibodies, especially in patients with a longer post-infection duration. Long-term follow-up studies are essential to understand the role of ANA in infection-triggered autoimmune conditions, enabling early diagnosis and treatment.- Book : 10(1)
- Pub. Date : 2025
- Page : pp.58-65
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2025
- Book : 53()
- Pub. Date : 2025
- Page : pp.100945-100945
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2025
AbstractIRF4, a transcription factor in the interferon regulatory factor family, is a key regulator in immune cell differentiation indicated to have an essential role in the development of lymphoid malignancies. Genome-wide association studies previously identified a set of overlapping mutations within the IRF4 DNA-binding domain in T-cell lymphoma and multiple myeloma, several of which appeared to be associated with better prognosis. Mapping these mutations to the known crystal structure of the IRF4:PU.1:DNA ternary complex and a new structure of the IRF4 DNA-binding domain in the apo state suggested they might interfere with DNA-binding, directly or via destabilisation of domain structure. We characterised these cancer-associated IRF4 mutants experimentally using the recombinant IRF4 DNA-binding domain (DBD)in vitroand examined the clinically relevant mutant K123Rin cellulo. Using fluorescence polarisation, surface plasmon resonance, differential scanning fluorimetry and molecular dynamics, we find that mutation may give rise to significant differences in DNA-binding kinetics and thermal stability without compromising the affinity of IRF4 DNA-binding. The K123R IRF4 mutant showed increased transcriptional activity via a luciferase reporter assay and increased nuclear partitioning, which may be preferentially selected for in multiple myeloma. We discuss our observations in relation to the improved prognosis conferred by this mutation.- Book : ()
- Pub. Date : 2025
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