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  • 2025


    • Book : 18(1)
    • Pub. Date : 2025
    • Page : pp.101266
    • Keyword :
  • 2025


    • Book : 18(1)
    • Pub. Date : 2025
    • Page : pp.101275
    • Keyword :
  • 2025


    • Book : 183()
    • Pub. Date : 2025
    • Page : pp.111892
    • Keyword :
  • 2025


    • Book : 36(1)
    • Pub. Date : 2025
    • Page : pp.16
    • Keyword :
  • 2025


    • Book : 18(1)
    • Pub. Date : 2025
    • Page : pp.101276
    • Keyword :
  • 2025

    Objective

    Antinuclear antibodies (ANA) staining patterns can provide useful information in systemic lupus erythematosus (SLE). In our study, we examined the frequency of ANA staining patterns in disease-related features in childhood-onset SLE patients.

    Methods

    ANA and its staining patterns were assessed in childhood-onset SLE patients.

    Results

    Two hundred twenty-three patients were included (F/M = 3/1). Their median age at diagnosis was 14.3 (11.9-16.1) years. The anti-cell (AC)-4/5 (fine or large speckled) pattern was the most common nuclear ANA pattern (75.8%), while the AC-19 (dense fine speckled) pattern was the most frequently detected cytoplasmic ANA pattern (13.1%). The AC-4/5 (fine or large speckled) patterns were notably seen in fever, acute and chronic cutaneous lupus, arthritis, serositis, hematologic involvement, renal involvement, neuropsychiatric involvement, gastrointestinal involvement, and cardiopulmonary involvement (all p < .001). Conversely, the AC-1 (homogeneous) pattern was significantly detected in oral/nasal ulcers and non-scarring alopecia (both p < .001). Regarding the laboratory features, the AC-4/5 (fine or large speckled) patterns exhibited a predominant seen in autoimmune hemolytic anemia, leukopenia, thrombocytopenia, elevated ESR and CRP, hypocomplementemia, direct Coombs, anti-Smith (Sm), anti-SSA and SS-B, anti-ribonucleoprotein (RNP), anti-histone, anti-ribosomal P, lupus anticoagulant, anti-cardiolipin immunoglobulin (Ig)M/IgG, and anti-β2-glycoprotein IgM/IgG positivities (all p < .001). In contrast, the AC-1 (homogeneous) pattern was detected in anti-double-stranded (ds) DNA and anti-histone positivity (both p < .001).

    Conclusion

    Our study showed that AC-4/5 and AC-1 patterns of ANA are frequently detected in many clinical and serological features of childhood-onset SLE patients. However, further studies are needed in larger populations to verify these results.


    • Book : 34(1)
    • Pub. Date : 2025
    • Page : pp.71-78
    • Keyword :
  • 2025


    • Book : 60()
    • Pub. Date : 2025
    • Page : pp.101099
    • Keyword :
  • 2025


    • Book : 99()
    • Pub. Date : 2025
    • Page : pp.111572
    • Keyword :
  • 2025


    • Book : 42()
    • Pub. Date : 2025
    • Page : pp.101853
    • Keyword :
  • 2025


    • Book : 132()
    • Pub. Date : 2025
    • Page : pp.110983
    • Keyword :